{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:06:40Z","timestamp":1789276000825,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photoactivation has been suggested to enhance the efficacy of platelet\u2010rich plasma (PRP) in conditions other than dermatological diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the efficacy of photoactivated PRP (P\u2010PRP) treatment for melasma by comparing it with non\u2010photoactivated, classical PRP (C\u2010PRP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study consisted of 38 female patients diagnosed with melasma between April 2022 and May 2023. The patients were randomized into the P\u2010PRP and C\u2010PRP groups. Three sessions of P\u2010PRP or C\u2010PRP were applied to the patients at 2\u2010week intervals. The Melasma Area and Severity Index (MASI) and Melasma Quality of Life Index (MELASQoL) scores were compared before and 2\u2009weeks after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 38\u2009years, and the median disease duration was 60\u2009months. Clinically, 94.7% of the cases were centrofacial and 5.3% were malar. According to Wood's lamp examination, 55.3% of the cases were epidermal, 13.2% were dermal, and 31.6% were mixed\u2010type. The median pre\u2010 and post\u2010treatment scores were 14.5 and 9, respectively, for MASI and 36.5 and 17, respectively, for MELASQoL. The post\u2010treatment MASI and MELASQoL scores of both groups significantly decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for both). However, the intergroup difference was not significant. When all patients were evaluated together a moderate, positive, and significant relationship was detected between PRP and the pre\u2010 and post\u2010treatment MASI and MELASQoL scores (<jats:italic>r<\/jats:italic>\u2009=\u20090.494 and <jats:italic>p<\/jats:italic>\u2009=\u20090.002). No side effects associated with PRP were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PRP is an effective and safe treatment method for melasma. Further studies are needed to evaluate the contribution of photoactivation to PRP treatment in melasma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16540","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T07:46:37Z","timestamp":1724399197000},"page":"3911-3917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of platelet\u2010rich plasma efficacy with and without photoactivation in melasma: A randomized double\u2010blind study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-1316","authenticated-orcid":false,"given":"Filiz Topalo\u011flu","family":"Demir","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Dermatological and Venereal Diseases Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8118-3405","authenticated-orcid":false,"given":"Ece","family":"Altun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Dermatological and Venereal Diseases Istanbul Medipol University  Istanbul 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