{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:23:17Z","timestamp":1793370197963,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin biorevitalization involves multiple intradermal injections to enhance skin quality, but precise dermal targeting can be challenging due to variations in skin thickness smaller, less painful needles with fewer skin reactions are attractive options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study evaluates a new Micro\u2010Needle device's performance and safety in comparison with the classic needle used in skin biorevitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Subjects with facial and neck skin aging were enrolled. Safety outcomes, including immediate and local tolerability, were assessed. Performance outcomes measured skin radiance, wrinkles and photoaging grade, hydration, subepidermal low echogenic band, dermis thickness, and skin elasticity. Both subjects and investigators recorded Global Aesthetic Improvement Scale scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Micro\u2010Needle injections demonstrated superior performance compared to the classic needle, influenced by the specific skin zones and thickness. Micro\u2010Needle was superior for skin wrinkles at D49 for periorbital zone and nasolabial folds by \u221214.5% (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) and \u221215% (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), respectively, and for neck by 9.6% (<jats:italic>p<\/jats:italic>\u2009=\u20090.0008). The Nanosoft device showed a faster improvement for skin hydration at D42 for the cheek zone (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) and at D75 for the neck area (<jats:italic>p<\/jats:italic>\u2009=\u20090.01); and for skin radiance at D75 (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and at D120 (<jats:italic>p<\/jats:italic>\u2009=\u20090.0098). Ex\u00a0vivo studies confirmed the Micro\u2010Needle's accuracy in product placement in the dermis. Adverse events were milder with Micro\u2010Needle and no serious adverse events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both needles significantly improved skin quality, but Micro\u2010Needle enhanced the outcomes of skin biorevitalization procedures, particularly in terms of skin wrinkle reduction, elasticity, and overall skin hydration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16547","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T16:39:18Z","timestamp":1727887158000},"page":"3974-3985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of the Performance and Safety of a New Micro\u2010Needle Technology in Comparison With the Classic Needle on the Antiaging Effects of a Biorevitalizing Solution: A\u00a0Randomized Split Face\/Neck Study"],"prefix":"10.1111","volume":"23","author":[{"given":"Andreea","family":"Boca","sequence":"first","affiliation":[{"name":"Private Clinic  Cluj Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3900-5506","authenticated-orcid":false,"given":"Ferial","family":"Fanian","sequence":"additional","affiliation":[{"name":"Scientific Department FILLMED Laboratories  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riekie","family":"Smit","sequence":"additional","affiliation":[{"name":"Private Clinic  Pertoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-3250","authenticated-orcid":false,"given":"Alessio","family":"Redaelli","sequence":"additional","affiliation":[{"name":"Genova University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranesha","family":"Goorochurn","sequence":"additional","affiliation":[{"name":"Dermo Dev Partners  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanane","family":"Issa","sequence":"additional","affiliation":[{"name":"Scientific Department FILLMED Laboratories  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sukmanskaya","sequence":"additional","affiliation":[{"name":"FILLMED Laboratories  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Philippon","sequence":"additional","affiliation":[{"name":"Private Clinic  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-4335","authenticated-orcid":false,"given":"Roberto","family":"Dell\u2019 Avanzato","sequence":"additional","affiliation":[{"name":"Private Clinic  Milan 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