{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:12:32Z","timestamp":1791828752743,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The primary aim of this systematic review and meta\u2010analysis was to synthesize and compare the clinical efficacy of intense pulsed light (IPL) and pulsed\u2010dye laser (PDL) therapies for the management of rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The literatures were searched in the Web of Science, PubMed, Embase, and Cochrane Library databases to identify relevant studies investigating the use of IPL and PDL for the treatment of rosacea. Screening of the retrieved articles and data extraction were performed as per the pre\u2010established inclusion and exclusion criteria. The primary outcome measures evaluated in this meta\u2010analysis included clearance rates, erythema scores, and pain scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The meta\u2010analysis incorporated data from four studies involving a total of 141 participants. The meta\u2010analysis did not reveal a statistically significant difference between IPL and PDL in the rate of achieving greater than 50% clearance (RR\u2009=\u2009\u22120.07, 95% CI: \u22120.19, 0.05). However, the IPL group demonstrated a significantly higher rate of clearance exceeding 75% compared to the PDL group (RR\u2009=\u2009\u22120.13, 95% CI: \u22120.23, \u22120.04). The change in erythema index, a key measure of rosacea severity, was similar between the two treatment modalities (SMD\u2009=\u2009\u22120.15, 95% CI: \u22120.55, 0.26). Interestingly, the PDL group reported a notably lower VAS pain score than the IPL group (SMD\u2009=\u20091.54, 95% CI: 0.08, 3.00).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Either PDL or IPL appears to be effective modalities for the management of rosacea. IPL exhibits a slight advantage in achieving a higher rate of substantial (&gt;75%) clearance, while PDL may be preferable for patients with lower tolerance for post\u2010treatment discomfort. However, the existing literature directly comparing these two laser\/light\u2010based therapies is limited, warranting further well\u2010designed, large\u2010scale studies to establish the optimal treatment algorithm for this chronic inflammatory skin condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16549","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T10:58:26Z","timestamp":1725620306000},"page":"3821-3827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Meta\u2010Analysis of the Efficacy of Intense Pulsed Light and Pulsed\u2010Dye Laser Therapy in the Management of Rosacea"],"prefix":"10.1111","volume":"23","author":[{"given":"Qianyu","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Dermatology Shenzhen Center for Chronic Disease Control  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen People's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen Center for Chronic Disease Control  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen Center for Chronic Disease Control  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen Center for Chronic Disease Control  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen Center for Chronic Disease Control  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.01.092"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1323644"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754241229365"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S391705"},{"key":"e_1_2_10_6_1","first-page":"167","article-title":"Treatment of Ocular Rosacea: A Systematic Review","volume":"22","author":"Avraham S.","year":"2024","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1775871"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13338"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06513.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16281"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2020.1774063"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02293.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.08.015"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13179"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1528371"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03357.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21151"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0301703"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2017.1361576"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16537.1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14816"},{"key":"e_1_2_10_22_1","first-page":"557","article-title":"The Pulsed\u2010Dye Laser for Treatment of Cutaneous Conditions","volume":"144","author":"Bernstein E. F.","year":"2009","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_264_22"},{"key":"e_1_2_10_24_1","first-page":"30","article-title":"Improving Treatment of Erythematotelangiectatic Rosacea With Laser and\/or Topical Therapy Through Enhanced Discrimination of Its Clinical Features","volume":"9","author":"Micali G.","year":"2016","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_25_1","first-page":"36","article-title":"Idiopathic Flushing With Dysesthesia: Treatment With the 585nm Pulsed Dye Laser","volume":"8","author":"Fogelman J. P.","year":"2015","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_26_1","first-page":"3543","article-title":"Improved Telangiectasia and Reduced Recurrence Rate of Rosacea After Treatment With 540 nm\u2010Wavelength Intense Pulsed Light: A Prospective Randomized Controlled Trial With a 2\u2010Year Follow\u2010Up","volume":"19","author":"Luo Y.","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_10_27_1","first-page":"45","article-title":"Current Trends in Intense Pulsed Light","volume":"5","author":"Goldberg D. J.","year":"2012","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_28_1","article-title":"Skin Cooling to Reduce the Pain Associated With Local Anesthetic Injection; a Randomized Controlled Trial","volume":"10","author":"Majidinejad S.","year":"2022","journal-title":"Archives of Academic Emergency Medicine"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.197028"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:32:42Z","timestamp":1741746762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/jocd.16549"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16549","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"2024-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}