{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:43:09Z","timestamp":1779892989425,"version":"3.53.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autologous fat grafting is a widely used technique in plastic and reconstructive surgery for soft tissue augmentation. Despite its advantages, the primary limitation is the unpredictable retention rate of transplanted fat. Recent studies suggest that botulinum toxin type A (BTX\u2010A) can enhance fat graft survival by promoting angiogenesis and muscle paralysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This review explores the potential of BTX\u2010A as an adjuvant in autologous fat grafting, providing insights into its mechanisms, benefits, and the need for further clinical validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>A literature review was conducted using PubMed, Web of Science, MEDLINE, and Embase. Keywords related to BTX\u2010A, fat grafting, fat graft survival, and angiogenesis were used. Comparative studies reporting histological changes following BTX\u2010A application in fat grafting were included. Exclusion criteria involved case reports with fewer than three animals, reviews, and letters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial search yielded 108 articles, with seven experimental studies meeting the criteria. These studies demonstrated that BTX\u2010A enhances fat graft retention by promoting vascularization and adipose\u2010derived stem cell differentiation. However, these results are mainly based on small animal models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While BTX\u2010A shows promise in improving autologous fat grafting outcomes, its efficacy and safety in humans need validation through large\u2010scale clinical trials. Translating these preclinical findings into human trials is crucial to establish standardized protocols and optimize clinical outcomes. Future research should focus on optimizing dosage and injection sites, conducting long\u2010term follow\u2010up studies, and performing multicenter trials to verify the findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16550","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T07:24:26Z","timestamp":1726903466000},"page":"3828-3835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Botulinum Toxin Type A in the Autologous Fat Grafting: A Review"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7377-6868","authenticated-orcid":false,"given":"Chihchieh","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and State Key Laboratory of Oral Diseases Sichuan University West China College of Stomatology  Chengdu Sichuan 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