{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:39:31Z","timestamp":1780569571215,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea, a chronic inflammatory skin condition, is marked by enduring redness, visible blood vessels, and inflammatory eruptions in facial areas. Managing rosacea remains a persistent challenge for dermatologists, especially in cases unresponsive to conventional treatments. Injectable poly\u2010<jats:sc>d,l<\/jats:sc>\u2010lactic acid (PDLLA) has shown promise in treating erythema and telangiectasia associated with rosacea in addition to age\u2010related concerns. Employing Mirajet, a laser\u2010induced microjet system, for administering PDLLA is a novel and promising treatment for rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to evaluate the efficacy and safety of injectable PDLLA delivered via a needle\u2010free microjet system for managing rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four Korean women with persistent and refractory rosacea received five monthly sessions of PDLLA needle\u2010free injections. Clinical assessments were conducted using the Clinician's Erythema Assessment and Patient's Self\u2010Assessment (PSA) at baseline, 4\u2009weeks post\u2010treatment, and 22\u2009weeks post\u2010final treatment. Adverse events were monitored throughout the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 4\u2009weeks post\u2010treatment, both Clinician's Erythema Assessment and PSA scores indicated significant improvements in erythema that were sustained up to the 22\u2010week follow\u2010up. Patients reported high satisfaction with resolution of redness and improved skin texture. Mild swelling, redness, and petechiae were observed post\u2010treatment but resolved spontaneously. No product\u2010related adverse events were noted during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Injectable PDLLA delivered via laser\u2010induced microjet injection demonstrated promising efficacy in improving rosacea symptoms and skin quality for up to 22\u2009weeks without significant adverse effects. Larger randomized controlled trials are needed to confirm these findings and evaluate long\u2010term safety and sustainability of outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16556","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:04:10Z","timestamp":1725879850000},"page":"3993-3998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Poly\u2010<scp>d<\/scp>,<scp>l<\/scp>\u2010Lactic Acid Via Transdermal Microjet Drug Delivery for Treating Rosacea in Asian Patients"],"prefix":"10.1111","volume":"23","author":[{"given":"Suk Bae","family":"Seo","sequence":"first","affiliation":[{"name":"SeoAhSong Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovian","family":"Wan","sequence":"additional","affiliation":[{"name":"Asia\u2010Pacific Aesthetic Academy  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Thulesen","sequence":"additional","affiliation":[{"name":"Capitol Eye Clinic  Copehagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Jalali","sequence":"additional","affiliation":[{"name":"One Clinic MD  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Vitale","sequence":"additional","affiliation":[{"name":"Private Practice  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project Yonsei University College of Dentistry  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-1364","authenticated-orcid":false,"given":"Kyu\u2010Ho","family":"Yi","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project Yonsei University College of Dentistry  Seoul Korea"},{"name":"Maylin Clinic (Apgujeong)  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03167.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2017.1361574"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13556"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_9_6_1","first-page":"17","article-title":"Adjunctive Skin Care in the Management of Rosacea: Cleansers, Moisturizers, and Photoprotectants","volume":"75","author":"Del Rosso J. 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