{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:49:14Z","timestamp":1793069354775,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The function of injectable hyaluronic acid\u2010based fillers is to smooth dermal wrinkles formed during aging. The aim of this study is to evaluate the performance and safety of a dermal filler after its commercialization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this context, an 18\u2010month prospective randomized single\u2010blind study for the efficacy and safety of ART FILLER Fine Lines (AFFL) was performed on the forehead, the upper lip, the cheek folds, and the crow's feet. The efficacy, the longevity, and the safety were evaluated after a single filler injection without any re\u2010touch injection. The persistence of the correction was evaluated at 3, 6, 9, 12, 15, and 18\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The observations performed on 196 subjects enrolled showed that AFFL injections induced a significant improvement in wrinkle correction for all the assessed areas. These effects were significant as soon as 3\u2009weeks after injection and remained significant until 18\u2009months. Furthermore, injections of AFFL were well tolerated and no severe event was recorded. The minor reported reactions were resolved within 3\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AFFL with Tri\u2010Hyal technology is suitable and well tolerated for the treatment of superficial wrinkles without any irregularity or Tyndall effect and showed a prolonged efficacy for at least 18\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16565","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T05:42:27Z","timestamp":1734673347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Performance and Safety of a Superficial\n                    <scp>HA<\/scp>\n                    Filler With Tri\u2010Hyal Technology on Different Facial Zones: Forehead, Cheeks, Crow's Feet, and Upper Lips"],"prefix":"10.1111","volume":"24","author":[{"given":"Hugues","family":"Cartier","sequence":"first","affiliation":[{"name":"Centre M\u00e9dical Saint Jean  Arras France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Private Practice  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Braccini","sequence":"additional","affiliation":[{"name":"Private Practice  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Garcia","sequence":"additional","affiliation":[{"name":"Private Practice  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Ehlinger","sequence":"additional","affiliation":[{"name":"Private Practice  Thionville France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"David","sequence":"additional","affiliation":[{"name":"Private Practice  Metz France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Loreto","sequence":"additional","affiliation":[{"name":"Private Practice  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Benadiba","sequence":"additional","affiliation":[{"name":"Private Practice  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Grand\u2010Vincent","sequence":"additional","affiliation":[{"name":"Private Practice  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Rumyantseva","family":"Mathey","sequence":"additional","affiliation":[{"name":"Alfa Medical Center  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Nadra","sequence":"additional","affiliation":[{"name":"Laboratoires FILL\u2010MED  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3900-5506","authenticated-orcid":false,"given":"Ferial","family":"Fanian","sequence":"additional","affiliation":[{"name":"Laboratoires FILL\u2010MED  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.00270.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80964-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1962.122"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.06.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(09)74530-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2004.12.002"},{"issue":"9","key":"e_1_2_7_8_1","first-page":"1059","article-title":"The Basic Science of Dermal Fillers: Past and Present Part I: Background and Mechanisms of Action","volume":"11","author":"Gilbert E.","year":"2012","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2005.01.022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13794"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.09.188"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12036"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01777.x"},{"issue":"9","key":"e_1_2_7_14_1","first-page":"1097","article-title":"The Effect of Lidocaine When Mixed With Large Gel Particle Hyaluronic Acid Filler Tolerability and Longevity: A Six\u2010Month Trial","volume":"9","author":"Lupo M. 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