{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:59:09Z","timestamp":1785549549545,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020638","name":"Allergan Aesthetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The SkinMedica Acne Treatment Platform (SM Regimen) was formulated to treat acne without overdrying the skin. We evaluated efficacy and tolerability of the SM Regimen (including a novel 1% salicylic acid Acne Clarifying Cleanser and 2% salicylic acid Acne Treatment Lotion) versus a prescription formulation (Rx Regimen; including adapalene 0.1%\/benzoyl peroxide 2.5%) in a diverse population of adults with mild to moderate facial acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, double\u2010blind, randomized study enrolled adults (18\u201345\u2009years) with Fitzpatrick skin types (FST) I\u2013VI. SM Regimen or Rx Regimen was applied topically to the entire face for 12\u2009weeks. Assessments were conducted at 24 and 48\u2009h and 4, 8, and 12\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Subjects (SM Regimen,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931; Rx Regimen,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) were primarily female (90.7%) with mean age of 28.6\u2009years; 53.8% had FST IV\u2013VI. Efficacy was comparable between regimens. The SM regimen resulted in significant improvements versus baseline in mean Investigator's Global Assessment of acne severity from 48\u2009h through week 12 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001), as well as significant and sustained improvements from baseline in total acne lesion count, global postinflammatory hyperpigmentation\/postinflammatory erythema, and oiliness. The SM Regimen was well tolerated at all time points, with mean scores below mild for all parameters; the Rx Regimen caused significantly more tightness\/dry feeling at week 4 versus SM Regimen (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Subjects (&gt;\u200996%) reported high satisfaction with the SM Regimen at all time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The SM Regimen reduced acne severity and skin oiliness, evening out skin tone without overdrying or irritating the skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16568","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T05:47:53Z","timestamp":1726811273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Tolerability of a Novel Cosmetic and Over\u2010the\u2010Counter Facial Acne Regimen Versus a Prescription Treatment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9971-2928","authenticated-orcid":false,"given":"Priscilla","family":"Huang","sequence":"first","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9734-5269","authenticated-orcid":false,"given":"Olivia","family":"Supan","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-3353","authenticated-orcid":false,"given":"Cecilia L.","family":"Pak","sequence":"additional","affiliation":[{"name":"SGS Stephens Inc.  Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-5847","authenticated-orcid":false,"given":"Rahul C.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-861X","authenticated-orcid":false,"given":"Elizabeth T.","family":"Makino","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0168-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304070-00004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S76088"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.040"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02768.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1144.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)80056-5"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S385162"},{"key":"e_1_2_11_11_1","first-page":"20","article-title":"Postinflammatory Hyperpigmentation: A Review of the Epidemiology, Clinical Features, and Treatment Options in Skin of Color","volume":"3","author":"Davis E. C.","year":"2010","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"945","key":"e_1_2_11_12_1","article-title":"Guidelines of Care for the Management of Acne Vulgaris","volume":"74","author":"Zaenglein A. L.","year":"2016","journal-title":"Journal of the American Academy of Dermatology"},{"key":"e_1_2_11_13_1","article-title":"Topical Azelaic Acid, Salicylic Acid, Nicotinamide, Sulphur, Zinc and Fruit Acid (Alpha\u2010Hydroxy Acid) for Acne","volume":"5","author":"Liu H.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_14_1","unstructured":"Galderma Laboratories 2013 Epiduo Gel (Package Insert) Fort Worth TX: Galderma Laboratories L.P."},{"key":"e_1_2_11_15_1","first-page":"278","article-title":"Adapalene\u2010Benzoyl Peroxide Once\u2010Daily, Fixed\u2010Dose Combination Gel for the Treatment of Acne Vulgaris: A Randomized, Bilateral (Split\u2010Face), Dose\u2010Assessment Study of Cutaneous Tolerability in Healthy Participants","volume":"81","author":"Andres P.","year":"2008","journal-title":"Cutis"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx034082r"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1996.tb06016.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.11.3009-3013.2001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.568032"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2017.1375636"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2008.07053"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105307084311"},{"key":"e_1_2_11_23_1","first-page":"19","article-title":"The Role of Skin Care as an Integral Component in the Management of Acne Vulgaris: Part 1: The Importance of Cleanser and Moisturizer Ingredients, Design, and Product Selection","volume":"6","author":"Del Rosso J. Q.","year":"2013","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00643-2"},{"key":"e_1_2_11_25_1","first-page":"46","article-title":"Easy as PIE (Postinflammatory Erythema)","volume":"6","author":"Bae\u2010Harboe Y. S.","year":"2013","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S427956"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003079"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13071433"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16568","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:39:31Z","timestamp":1773758371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jocd.16568"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16568","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]},"assertion":[{"value":"2024-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16568"}}