{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:51:54Z","timestamp":1785261114980,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Poly\u2010\n                      <jats:sc>l<\/jats:sc>\n                      \u2010lactic acid (PLLA) injectables have gained increasing attention in aesthetic medicine due to their biocompatibility and long\u2010lasting effects. Although their primary application centers around facial rejuvenation, their potential for off\u2010label use in other body areas has been investigated, demonstrating promising outcomes in terms of both efficacy and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to assess the safety and efficacy of a novel 630\u2009mg PLLA\u2010based filler (GANA X), in buttocks treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six physicians treated 51 patients for buttock aesthetic treatment across six different medical facilities in Italy. A survey was filled by both physicians and patients regarding treatment safety, efficacy, and change in quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We reported minor or mild adverse events, self\u2010resolving within the next few days. Both physicians and patients confirmed notable aesthetic improvements following treatment, varying from moderate to significant enhancement. These effects endured throughout follow\u2010up visits spanning up to 24\u2009months. Patient\u2010reported outcomes indicated elevated self\u2010esteem and improved quality of life posttreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high level of satisfaction reported by both physicians and patients highlights the efficacy and tolerability of GANA X filler for buttocks treatment, encouraging their use and research for off\u2010label body areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16580","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T06:40:17Z","timestamp":1729752017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multicentric Retrospective Study on Safety and Efficacy of a Novel Injectable Poly\u2010\n                    <scp>l<\/scp>\n                    \u2010Lactic Acid for Buttocks Recontouring"],"prefix":"10.1111","volume":"24","author":[{"given":"Paola Rosalba","family":"Russo","sequence":"first","affiliation":[{"name":"Private Practitioner, Esteemed Aesthetic Clinic  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Bovani","sequence":"additional","affiliation":[{"name":"Private Practitioner, Esculapio  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Private Practitioner, DeA Center Laser &amp; Plastic Surgery Clinic  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Forte","sequence":"additional","affiliation":[{"name":"Private Practitioner, RF Clinics  Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Vercesi","sequence":"additional","affiliation":[{"name":"Private Practitioner, Centro Medico Galeno  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-154X","authenticated-orcid":false,"given":"Giovanni","family":"Salti","sequence":"additional","affiliation":[{"name":"Private Practitioner, Medlight Medical Institute  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S359813"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-017-0798-y"},{"key":"e_1_2_11_4_1","unstructured":"Plastic Surgery Statistics \u201cAmerican Society of Plastic Surgeons \u201d2020 https:\/\/www.plasticsurgery.org\/news\/plastic\u2010surgery\u2010statistics."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics10040110"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA04321E"},{"key":"e_1_2_11_7_1","first-page":"s32","article-title":"The History Behind the Use of Injectable Poly\u2010l\u2010Lactic Acid for Facial and Nonfacial Volumization: The Positive Impact of Evolving Methodology","volume":"13","author":"Vleggaar D.","year":"2014","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002141"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.01061.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000234612.20611.5a"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2008.06.005"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01375.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2013.337"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2012.00609.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5631"},{"key":"e_1_2_11_16_1","first-page":"345","article-title":"\u00c1cido Poli\u2010L\u2010L\u00e1ctico: Um Agente Bioestimulador","volume":"5","author":"Filho C. 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