{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:16:02Z","timestamp":1791915362637,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periorbital hyperpigmentation is a prevalent skin condition that represents a large quantity of cases seen in cosmetic dermatology. Patients tend to be left with pigmentation after Q\u2010switched ruby laser treatment, especially the perioribital area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study is conducted to compare the effect of PRP injection combined with laser therapy versus laser alone for periorbital hyperpigmentation treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>In this single\u2010center, case\u2013control study, 30 patients with periorbital hyperpigmentation were allocated to receive PRP injection injection after Q\u2010switched ruby laser or Q\u2010switched ruby laser only, followed by a 12\u2010week and 24\u2010week follow\u2010up visit. Visual analogue scale, Sadick tear trough rating scale, and patients' self\u2010evaluation were used to evaluate the therapeutic effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The combined group achieved a better improvement in long\u2010term effect and had effect on facial rejuvenation. Patient satisfaction was higher in the combined group. Erythema and mild pain were the most common adverse reactions of both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combining with PRP injection can improve the therapeutic effect of Q\u2010switched ruby laser in treating periorbital hyperpigmentation and lessen the risk of post\u2010inflammatory hyperpigmentation, indicating a new option for POH treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16598","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T07:24:25Z","timestamp":1727249065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Platelet\u2010Rich Plasma Injection Combined With Q\u2010Switched Ruby Laser in the Treatment of Periorbital Hyperpigmentation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-856X","authenticated-orcid":false,"given":"Yankun","family":"Lu","sequence":"first","affiliation":[{"name":"Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Lin","sequence":"additional","affiliation":[{"name":"Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Fang","sequence":"additional","affiliation":[{"name":"Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-495X","authenticated-orcid":false,"given":"Han","family":"Ma","sequence":"additional","affiliation":[{"name":"Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_303_17"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"49","article-title":"Periorbital Hyperpigmentation: A Comprehensive Review","volume":"9","author":"Sarkar R.","year":"2016","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.99436"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15497"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22754"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1995.tb00293.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29291.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1832189"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.036"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02173-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12072"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14036"},{"issue":"7","key":"e_1_2_11_14_1","article-title":"Platelet\u2010Rich Plasma for Skin Rejuvenation and Treatment of Actinic Elastosis in the Lower Eyelid Area","volume":"10","author":"Aust M.","year":"2018","journal-title":"Cureus"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00336.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.05.036"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002484"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2018.30.5.522"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2635-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2416-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00309.2022"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02267.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01916.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:38:11Z","timestamp":1773758291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,25]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jocd.16598"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16598","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,25]]},"assertion":[{"value":"2024-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16598"}}