{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:42:25Z","timestamp":1773769345918,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Light\u2010emitting diode (LED) light sources have become an increasingly popular choice for the treatment and rejuvenation of various dermatological conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of neck rejuvenation, patient satisfaction, and the safety of LED application to the neck in an Asian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter, randomized, double\u2010blind, sham device study. Seventy participants were enrolled in the study. The participants wore the home\u2010use LED neck device for 9\u2009min a day, 5 times a week, for a total of 60 sessions. The Lemperle Wrinkle Scale (LWS) and Global Aesthetic Improvement Scale (GAIS) were used to evaluate the results of both investigators and participants. The thyroid gland was examined using ultrasonography to evaluate the safety of the investigational device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The percentage of participants with improved LWS at Week 12 was significantly higher in the study group. Additionally, the percentage of participants with improved LWS was significantly higher in the study group at Weeks 8, 12, and 16. The LWS at Week 12 corrected with baseline values was found to be significantly different between the two groups. GAIS showed significant differences at 8, 12, and 16\u2009weeks in the investigators' evaluation but not in the participants' evaluation. Repeated\u2010measures analysis of variance at Weeks 4, 8, 12, and 16 also confirmed a significant difference between the two groups only in investigator assessment. No significant thyroid\u2010related complications were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LED application to the neck may be considered a satisfactory and safe procedure for neck rejuvenation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16599","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T07:42:04Z","timestamp":1727250124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of a Home\u2010Use Light\u2010Emitting Diode Neck Device for Improvement in Neck Wrinkles: A Multicenter, Randomized, Double\u2010Blind, Sham Device, Superiority Verification, Confirmatory Clinical Trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8990-0635","authenticated-orcid":false,"given":"Seong Oh","family":"Park","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8879-2985","authenticated-orcid":false,"given":"Jiwoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3859-623X","authenticated-orcid":false,"given":"Sang Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hanyang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-9634","authenticated-orcid":false,"given":"Jae\u2010A","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hanyang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-9565","authenticated-orcid":false,"given":"Chihwan","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Surgery Hanyang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hanyang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Kwon","family":"An","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hanyang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"301","volume-title":"Plastic Surgery","author":"Zins J. 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