{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:32:00Z","timestamp":1776353520265,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012253"],"award-info":[{"award-number":["2022A1515012253"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110487"],"award-info":[{"award-number":["2023A1515110487"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The occurrence of scalp seborrheic dermatitis (SD) is closely related to the production of sebum and scalp barrier function. Supramolecular salicylic acid has the keratolytic and anti\u2010inflammatory properties, and zinc pyrithione is an antifungal drug delivered as a microparticle to skin epithelia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess the efficacy and safety of 2% supramolecular salicylic acid (SSA) combined with 0.8% zinc pyrithione conditioner (SSA\u2010ZP) in treating scalp SD focusing on key outcome measures including sebum levels and scalp barrier function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five patients with mild to moderate scalp SD were included in the 2\u2010week self\u2010controlled prospective study, receiving daily SSA\u2010ZP treatment. Evaluation on days 0, 7, and 14 included dermoscopy, the adherent scalp flaking scale (ASFS), sebum level, transepidermal water loss (TEWL), pH, and stratum corneum hydration. We also performed the fungal count across specific scalp regions, such as the left and right sides of the forehead, the top of the head, and the occiput.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five patients with mild to moderate scalp SD participated in this study. After 2\u2009weeks of SSA\u2010ZP treatment, significant reductions in ASFS scores, sebum levels, and fungal count were observed, alongside improvements in TEWL and pH values across multiple scalp regions. Moreover, there was no difference in the hydration of stratum corneum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SSA\u2010ZP demonstrated efficacy in treating scalp SD without adverse effects, suggesting its potential as a first\u2010line treatment option. Further research with larger sample sizes and longer follow\u2010up periods is warranted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16617","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T14:15:45Z","timestamp":1730124945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>SSA<\/scp>\n                    \u2010\n                    <scp>ZP<\/scp>\n                    on Scalp Seborrheic Dermatitis: Regulating Sebum Levels and Scalp Barrier"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-5687","authenticated-orcid":false,"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Fuyang People's Hospital  Fuyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congxiu","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lintong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3939-293X","authenticated-orcid":false,"given":"Xiaowen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-2375","authenticated-orcid":false,"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Department of Dermatology and Venereology Fuyang People's Hospital  Fuyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529854"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14450"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00693.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14799"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14623"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13923"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-020-02333-5"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad168"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.687089"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189730"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701017"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12055"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00607.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10573.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2023.01.023"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12050"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1473554"},{"issue":"12","key":"e_1_2_11_20_1","first-page":"1196","article-title":"Salicylic Acid Peels for the Treatment of Acne Vulgaris in Asian Patients","volume":"29","author":"Lee H. 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