{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:43:40Z","timestamp":1773769420296,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sensitive skin is a worldwide skin problem, and its assessment of therapeutic efficacy traditionally relies on the facial stinging test. However, this test possesses certain limitations due to its restrictive application site, intense pain sensation, and adverse effects on physical appearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to develop and evaluate a highly efficient and user\u2010friendly sensitive skin simulation model, which combines tape stripping and capsaicin testing on the forearm (FA\u2010TS\u2010CAT), as an alternative to the facial stinging test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A randomized, double\u2010blind, placebo\u2010controlled clinical trial was conducted involving 74 subjects. Skin redness (\n                      <jats:italic>a<\/jats:italic>\n                      * value), transepidermal water loss (TEWL), and self\u2010assessment questionnaires were collected at different time points for analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tape stripping 5 times and 10\u2009min application of capsaicin test were identified as the optimal conditions for the FA\u2010TS\u2010CAT model. Consistent stimulation and natural recovery trends of\n                      <jats:italic>a<\/jats:italic>\n                      * value and TEWL were observed on both the FA\u2010TS\u2010CAT and facial capsaicin test (F\u2010CAT) models within 50\u2009min. After the 4\u2010\n                      <jats:italic>t<\/jats:italic>\n                      \u2010butylcyclohexanol complex emulsion was applied, the\n                      <jats:italic>a<\/jats:italic>\n                      * value in the FA\u2010TS\u2010CAT model exhibited a soothing trend similar to the F\u2010CAT model, with a significantly reduced by 3.99\u2010fold and 3.28\u2010fold at T3 and T4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), compared to the placebo. Notably, the test efficiency of the FA\u2010TS\u2010CAT model was threefold higher than that of the F\u2010CAT model, and subjects showed more willingness to participate in the FA\u2010TS\u2010CAT test (95.95% vs. 4.05%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicated the FA\u2010TS\u2010CAT is a highly efficient and user\u2010friendly model for sensitive skin, providing a reliable and valid method for clinical research in sensitive skin treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16619","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T05:48:45Z","timestamp":1728452925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Highly Efficient and User\u2010Friendly Sensitive Skin Model on the Forearm"],"prefix":"10.1111","volume":"24","author":[{"given":"Jianhua","family":"Zhang","sequence":"first","affiliation":[{"name":"N.O.D Topia (GuangZhou) Biotechnology Co., Ltd.  Guangdong Guangzhou China"},{"name":"Simpcare (GuangZhou) Biotechnology Co., Ltd.  Guangdong Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shichao","family":"Liu","sequence":"additional","affiliation":[{"name":"N.O.D Topia (GuangZhou) Biotechnology Co., Ltd.  Guangdong Guangzhou China"},{"name":"Simpcare (GuangZhou) Biotechnology Co., Ltd.  Guangdong Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjiao","family":"Guo","sequence":"additional","affiliation":[{"name":"N.O.D Topia (GuangZhou) Biotechnology Co., Ltd.  Guangdong Guangzhou China"},{"name":"Simpcare (GuangZhou) Biotechnology Co., Ltd.  Guangdong Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-4149","authenticated-orcid":false,"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"N.O.D Topia (GuangZhou) Biotechnology Co., Ltd.  Guangdong Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Huang","sequence":"additional","affiliation":[{"name":"N.O.D Topia (GuangZhou) Biotechnology Co., Ltd.  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