{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T21:33:49Z","timestamp":1781991229530,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiofrequency (RF) microneedling produces patient discomfort which deters patients from completing the recommended treatment series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The primary objective was to determine the tolerability, safety, and efficacy of a neurocosmetic postprocedure cream post\u2010RF microneedling in reducing patient discomfort and enhancing recovery across the length of the study and, secondarily, to evaluate against a leading comparator. The third objective was to evaluate the efficacy of the neurocosmetic on self\u2010perceived improvement and objective grading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>An Institutional Review Board (IRB) approved, fourteen\u2010day, randomized, single\u2010center, double\u2010blind, controlled clinical case study was conducted with 11 healthy female subjects, 6 randomized to the neurocosmetic and 5 to the comparator cell. Following a 7\u2010day washout period, subjects received RF microneedling (face and neck) and applied the postprocedure cream twice daily for 7\u2009days. Objective and subjective tolerability, self\u2010assessments, and clinical photography were performed immediately postprocedure, 24\u2009h, three and seven days following the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The neurocosmetic was tolerable and safe. Erythema and stinging immediately decreased postprocedure, postneurocosmetic application. After 24\u2009h, 83% favorably agreed the neurocosmetic \u201creduced irritation on the skin post\u2010procedure,\u201d and after 7\u2009days, 100% favorably agreed \u201cexperience with the product was positive and I would be interested in returning for a second treatment.\u201d The neurocosmetic reduced skin tone redness in the face and neck faster and to a greater degree when measured against a comparator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The neurocosmetic postprocedure cream improved patient discomfort and enhanced recovery when used immediately post\u2010RF microneedling and after 7\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>IRB Protocol Number<\/jats:title><jats:p>Pro00064211<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16622","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T14:37:58Z","timestamp":1728571078000},"page":"4077-4084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Randomized, Single\u2010Center, Double\u2010Blind, Controlled Case Study Evaluating Procedure Pairing of a Neurocosmetic Postprocedure Cream With Radiofrequency Microneedling for Facial Rejuvenation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1621-6458","authenticated-orcid":false,"given":"McKenzie E.","family":"Maloney","sequence":"first","affiliation":[{"name":"Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Iglesia","sequence":"additional","affiliation":[{"name":"Revision Skincare  Irving Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kononov","sequence":"additional","affiliation":[{"name":"Revision Skincare  Irving Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-0776","authenticated-orcid":false,"given":"Alisar S.","family":"Zahr","sequence":"additional","affiliation":[{"name":"Revision Skincare  Irving Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-5433","authenticated-orcid":false,"given":"Michael H.","family":"Gold","sequence":"additional","affiliation":[{"name":"Gold Skin Center Tennessee Clinical Research Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212489"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9111564"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13116"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.724534"},{"key":"e_1_2_9_7_1","first-page":"1","volume-title":"Enhanced Liposuction\u2010New Perspectives and Techniques","author":"Kreindel M.","year":"2021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz055"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18854"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojz017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2003.12.4.26484"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.3.122"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871528113666140522104422"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010642\u201054215\u20102_9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2280"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2010.01122.x"},{"key":"e_1_2_9_17_1","unstructured":"ImageJ Image Processing and Analysis in Java. 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