{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T01:34:37Z","timestamp":1778981677974,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The demand for aesthetic treatments targeting the middle and lower face is on the rise, especially because of changes in appearance associated with aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to assess the use of a hybrid filler for sculpting and contouring of the chin, jaw, and malar region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on patients who underwent jaw and chin contouring and cheek augmentation using a hybrid filler (hyaluronic acid and dextranomer). The evaluation focused on the naturalness of appearance, enhancement in volume, and the durability of the results, employing a 5\u2010point scale. Both patient satisfaction and physician evaluations were measured using the Likert scale and the Global Aesthetic Improvement Scale (GAIS), respectively. Follow\u2010up with patients extended up to 6\u2009months after treatment, during which any treatment\u2010related adverse events (AEs) were meticulously recorded and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen patients participated in the study, receiving an average injection volume of 2.4\u2009\u00b1\u20090.9\u2009mL to attain the desired outcomes. The evaluation of natural appearance, volumizing effects, and durability at the analyzed time point consistently scored above 4. All 19 patients' aesthetic improvement was evaluated as \u201cvery much improved\u201d and \u201cmuch improved\u201d, at the GAIS score. All patients report improvement in their appearance, with 89.5% rating it as \u201cvery much improved\u201d or \u201cmuch improved\u201d on the Likert scale. Only expected AEs such as mild pain and lower swelling were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The hybrid filler proved effective and safe for facial contouring, with significant patient satisfaction and minimal adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16653","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T04:32:54Z","timestamp":1730867574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Outcomes and Safety Profile of a Dextranomer\u2013Hyaluronic Acid Hybrid Filler: A Case Series Analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Nazaret","family":"Ruiz","sequence":"first","affiliation":[{"name":"Private Clinic  Gij\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Miranda","family":"Lopez","sequence":"additional","affiliation":[{"name":"Hospital Cruz Roja  Gij\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Marques","sequence":"additional","affiliation":[{"name":"Medical Department BioScience GmbH  Madrid Spain"},{"name":"Institute of Biomedicine (IBIOMED) University of Le\u00f3n  Le\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1972-6349","authenticated-orcid":false,"given":"Silvia","family":"Fontenete","sequence":"additional","affiliation":[{"name":"Medical Department BioScience GmbH  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2005.11.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8332631"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000003388"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1725164"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003716"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20102077.167264"},{"issue":"6","key":"e_1_2_11_8_1","first-page":"652","article-title":"Twenty\u2010Four\u2010Week Multicenter, Evaluator\u2010Blinded Clinical Study of the Efficacy and Safety of a Dextran Filler in the Treatment of Nasolabial Folds","volume":"40","author":"Shin S. 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