{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:28:38Z","timestamp":1784230118078,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"S5","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic telogen effluvium (CTE) is characterized by hair loss lasting for more than 6\u2009months and severely impairs quality of life (QoL). There is no specific treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the dermatological tolerance and clinical efficacy of a hair serum containing three plant\u2010derived active ingredients (a <jats:italic>Silybum marianum<\/jats:italic> extract, Manganese PCA, and a <jats:italic>Lespedeza capitata<\/jats:italic> extract) in women with CTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this 16\u2010week, open\u2010label, two\u2010arm, controlled, parallel\u2010group study, 64 women aged 46\u2009\u00b1\u200910\u2009years with CTE and a positive hair pull test were allocated equally to either a treated group (study serum and neutral shampoo) or a control group (neutral shampoo only).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The investigator rated dermatological tolerance of the serum as good at week (W)16. Compared to the control group, reductions in the amount of hair collected by the investigator during hair pull tests were greater in the treated group at W8 (<jats:italic>p<\/jats:italic>\u2009=\u20090.027) and W16 (<jats:italic>p<\/jats:italic>\u2009=\u20090.030), the amount of hair shed in 60\u2009s (assessed by the subjects) was significantly lower in the treated group from W4, and more subjects in the treated group reported a decrease in hair loss over the study period (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.01; all time points). The treated subjects also perceived a significant improvement in hair volume, density, strength, and thickness, and reported being less depressed, less annoyed and less embarrassed by their hair loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The serum was well\u2010tolerated and had a significant anti\u2010hair loss effect in women with CTE. This effect positively impacted QoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16656","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T11:05:42Z","timestamp":1732791942000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Well\u2010Tolerated Hair Serum Containing New Natural Active Ingredients Reduced Hair Loss and Improved Quality of Life in Women With Chronic Telogen Effluvium: A 16\u2010Week Controlled Study"],"prefix":"10.1111","volume":"23","author":[{"given":"Virginie","family":"Turlier","sequence":"first","affiliation":[{"name":"D\u00e9partement D\u00e9veloppement et Expertise Clinique et Sensorielle R&amp;D Pierre Fabre Dermo\u2010Cosm\u00e9tique et Personal Care  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Froliger","sequence":"additional","affiliation":[{"name":"D\u00e9partement 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