{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:52:09Z","timestamp":1791496329043,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Refractory melasma remains a challenge in dermatology, necessitating the exploration of innovative treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to evaluate the efficacy and safety of combining radiofrequency microneedling (RFM) with Cysteamine cream, applied both in\u2010office and as a part of a home\u2010care regimen, to treat refractory melasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>A vehicle\u2010controlled, split\u2010face trial was conducted on 30 Fitzpatrick skin types III and IV participants. Subjects received RFM and Cysteamine serum on one side of the face and RFM with saline on the contralateral side. Additionally, a random half\u2010added Cysteamine cream was applied at home. The modified Melasma Area and Severity Index and VISIA skin analysis were used for assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant improvement in melasma severity and skin texture was noted on the sides treated with RFM and Cysteamine, including observable benefits from both in\u2010office and home\u2010based Cysteamine use with minimal adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combined approach of RFM with Cysteamine provides a promising and safe modality for managing refractory melasma, showing notable improvements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16661","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:08:43Z","timestamp":1732248523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Safety of Combination Therapy of Microneedling Radiofrequency, In\u2010Office and Home\u2010Based Topical Cysteamine in Refractory Melasma: A Split Face, Vehicle\u2010Control, Randomized Control Trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Ya\u2010Wen","family":"Tsai","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Dermatology Chang Gung Memorial Hospital  Taipei Linkou Taiwan"},{"name":"Department of Dermatology and Aesthetic Medicine Center Jen\u2010Ai Hospital  Tai Chung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng\u2010Hsien","family":"Lin","sequence":"additional","affiliation":[{"name":"Dr. LIN's Dermatological Clinic  Kaohsiung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Jing","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Dermatology Chang Gung Memorial Hospital  Taipei Linkou Taiwan"},{"name":"Department of Dermatology and Aesthetic Medicine Center Jen\u2010Ai Hospital  Tai Chung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-8558","authenticated-orcid":false,"given":"Tzu\u2010Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau Yee","family":"Ng","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Dermatology Chang Gung Memorial Hospital  Taipei Linkou Taiwan"},{"name":"Department of Dermatology and Aesthetic Medicine Center Jen\u2010Ai Hospital  Tai Chung Taiwan"},{"name":"Vitiligo Clinic and Pigment Research Center Chang Gung Memorial Hospital  Linkou 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