{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:51:42Z","timestamp":1791496302131,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Earlier, quickly alternating dual\u2010frequency ultrasound waves (LDM technology) were successfully applied for the treatment of different inflammatory skin conditions such as rosacea and acne. In this retrospective pragmatic two\u2010center clinical study, we applied the triple\u2010frequency LDM (TF\u2010LDM) technology with frequencies of 1\/3\/10 and 3\/10\/19\u2009MHz for the treatment of mild\u2010to\u2010severe acne skin to assess the effectivity and sustainability of the treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010two patients with mild\u2010to\u2010severe acne were included in this study: 11 patients were treated with TF\u2010LDM (1\/3\/10\u2009MHz), and other 11 patients\u2014with TF\u2010LDM (3\/10\/19\u2009MHz). Assessment of the acne severity was done using the bilateral facial photographs. The photos were evaluated at baseline (T1), on the day of the last treatment (T2), and during the follow\u2010up controls (T3). Assessment of the acne severity was provided in accordance with a modified Global Evaluation Acne (mGEA) scale by nine independent dermatologists who were blinded to treatment assignments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average improvement of the mGEA scoring between T1 and T2 across all patients was 73.69%\u2009\u00b1\u200913.90% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), whereas the skin improvement between T1 and T3 was 90.14%\u2009\u00b1\u20098.35% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The state of the skin was also statistically significantly improved between T2 and T3 (53.26%\u2009\u00b1\u200929.24%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.02). There was no difference in treatment outcomes between the patients treated with TF\u2010LDM (1\/3\/10\u2009MHz) and TF\u2010LDM (3\/10\/19\u2009MHz).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TF\u2010LDM is an effective method for the treatment of the mild\u2010to\u2010severe acne skin that provides a significant skin improvement and long\u2010lasting treatment results. The method demonstrates no significant side effects, is pain\u2010free, well tolerated, and highly accepted by patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16672","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T01:55:19Z","timestamp":1731894919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Retrospective Pragmatic Two\u2010Center Clinical Study to Evaluate the Clinical Outcome of Triple\u2010Frequency Ultrasound in the Treatment of Mild\u2010to\u2010Severe Acne Vulgaris"],"prefix":"10.1111","volume":"24","author":[{"given":"Irina G.","family":"Chervinskaya","sequence":"first","affiliation":[{"name":"Clinic DK Forma  St Petersburg Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia V.","family":"Gaidash","sequence":"additional","affiliation":[{"name":"Clinic TriActive  Moscow Russian 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