{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:52:02Z","timestamp":1791496322843,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH046"],"award-info":[{"award-number":["ZR2023MH046"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["202320001415"],"award-info":[{"award-number":["202320001415"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent preclinical studies have demonstrated the potential efficacy of stem cell exosomes in the treatment of hair loss. However, there is a paucity of clinical studies investigating the application of exosomes for this purpose. This case series presents three patients treated with exosomes for acquired trichorrhexis nodosa (ATN), a condition characterized by hair shaft abnormalities and breakage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to evaluate the effectiveness and safety of utilizing mesenchymal stem cell (MSC) exosomes as a novel therapeutic approach for the management of ATN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A standardized process was employed to prepare 0.1\u2009mL of exosomes, which were subsequently injected into bilateral regions of the patients' scalps at 0.5\u20131\u2009cm intervals on a monthly basis. Each injection comprised a total volume of 5\u2009mL, and all three patients underwent a minimum of four treatment sessions. The comparative efficacy of the treatment was evaluated using clinical photographs, dermatoscopy, and scanning electron microscopy (SEM) for all three patients post\u2010intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The hair condition of the three patients demonstrated significant improvement, characterized by increased length and density, enhanced pigmentation with a reduced presence of dusty white dots, and the disappearance of dermoscopic black dots and broken hairs. SEM analysis revealed a remarkable recovery in the hair cuticle layers. At the 1\u2010year follow\u2010up, hair growth essentially remained normal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exosomes derived from mesenchymal stem cells demonstrate efficacy in treating ATN, presenting a novel therapeutic approach for this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16683","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T03:59:14Z","timestamp":1732507154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mesenchymal Stem Cell Exosomes Therapy for Acquired Trichorrhexis Nodosa: A Case Series"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9774-2742","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Pang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianke","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Mi","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbo","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratory for Stem Cell and Regenerative Medicine Affiliated Hospital of Shandong Second Medical University  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong 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