{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:13:12Z","timestamp":1791828792132,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Surgical scars with textural changes can be disfiguring and uncomfortable for patients. Various laser therapies have shown promise in softening and flattening these scars. Therefore, the authors conducted a systematic review and meta\u2010analysis on the efficacy of fractional CO\n 2<\/jats:sub>\n laser in treating surgical scars.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to present evidence from controlled trials investigating the efficacy of ablative carbon dioxide fractional laser in treating surgical scars.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n A literature search of Medline (via PubMed), Ovid, Web of Science, and Embase for relevant trials was conducted before March 2024. After assessing for inclusion, data extraction was performed using Population, Intervention, Comparison, Outcomes and Study criteria (PICOS). Quality, validity, and risk of bias were assessed using the RevMan5.3 risk of bias assessment tool.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 14 controlled trials involving 492 participants or postsurgical scars were included in the system review and meta\u2010analysis. Both in RCT and non\u2010RCT settings, fractional CO\n 2<\/jats:sub>\n laser therapy exhibited the same efficacious outcomes, with MD values of \u22120.63 (95% CI: \u22121.15 to \u22120.12; I\n 2<\/jats:sup>\n \u2009=\u200970%;\n p<\/jats:italic>\n \u2009=\u20090.02) and\u2009\u2212\u20091.86 (95% CI: \u22122.65 to \u22121.07; I\n 2<\/jats:sup>\n \u2009=\u200985%;\n p<\/jats:italic>\n \u2009<\u20090.001), respectively. Moreover, furthermore analysis illustrated that initiating FRACTIONAL CO2 LASER treatment sessions at or within 1\u2009month after surgery significantly reduced postoperative scars compared to control groups and groups on treatments initiated more than 3\u2009months after surgery (MD: \u20101.66; 95% CI: \u22122.31 to \u22121.01; I\n 2<\/jats:sup>\n \u2009=\u200989%;\n p<\/jats:italic>\n \u2009<\u20090.001 and MD: \u20101.93; 95% CI: \u22122.24 to \u22121.62; I\n 2<\/jats:sup>\n \u2009=\u200948%;\n p<\/jats:italic>\n \u2009<\u20090.001). However, fractional CO\n 2<\/jats:sub>\n laser treatment administered over 3\u2009months after surgery did not significantly improve postoperative scars (MD: \u20130.17; 95% CI: \u22120.56 to 0.21; I\n 2<\/jats:sup>\n \u2009=\u200937%;\n p<\/jats:italic>\n \u2009=\u20090.37).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The systematic review and meta\u2010analysis provide robust support for the efficacy of fractional CO\n 2<\/jats:sub>\n laser in treating surgical scars, particularly when administered at or within 1\u2009month after surgery. One treatment session within 1\u2009month after surgery also can produce significant results, but most clinical trials support 2\u20133 treatment sessions or more.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.16708","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T02:12:29Z","timestamp":1736388749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Fractional\n \n CO\n 2<\/sub>\n <\/scp>\n Laser to Treat Surgical Scars: A System Review and Meta\u2010Analysis on Optimal Timing"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-8654","authenticated-orcid":false,"given":"Qiang","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Aesthetic Plastic Surgery, West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Aesthetic Plastic Surgery, West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Aesthetic Plastic Surgery, West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-8910","authenticated-orcid":false,"given":"He","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Aesthetic Plastic Surgery, West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Aesthetic Plastic Surgery, West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.33030.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199910000-00031"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-021289"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2008.03.020"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04222.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001815"},{"issue":"7","key":"e_1_2_10_8_1","first-page":"1","article-title":"Efficacy of Fractional Carbon Dioxide Laser Therapy for Burn Scars: A Meta\u2010Analysis","volume":"32","author":"Zhang C.","year":"2019","journal-title":"Journal of Dermatological 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