{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:52:02Z","timestamp":1791496322818,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Yunnan\u2013Guizhou Plateau's high\u2010altitude setting is characterized by intense solar ultraviolet radiation, a significant environmental stressor that frequently leads to skin barrier damage. This damage presents clinically as erythema, itching, and desquamation, underscoring the need for effective reparative interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The objective of this study was to assess the therapeutic efficacy of a novel treatment protocol that integrates non\u2010crosslinked hyaluronic acid (HA) injection with microneedle application of human epidermal growth factor (hEGF) for the restoration of skin barrier function in regions of high altitude.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty female subjects exhibiting characteristic signs of skin barrier impairment were randomized into four cohorts: a control group and three experimental groups differentiated by hEGF concentration. The intervention comprised subdermal HA injection coupled with microneedle therapy. The VISIA digital skin analysis system was utilized to quantify skin barrier integrity, with assessments performed by a panel of dermatologists and through patient self\u2010evaluations at baseline and postintervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A marked reduction in erythema and indices of skin barrier damage was observed in the experimental groups relative to the control. The cohort administered 10\u2009000\u2009IU hEGF exhibited the most pronounced restoration of skin barrier function, indicative of a dose\u2010dependent therapeutic response. The treatment demonstrated favorable tolerability without any reported adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The conjoint application of non\u2010crosslinked HA and hEGF presents as a potent therapeutic modality for the repair of the skin barrier in high\u2010altitude environments. Our findings indicate that an optimized concentration of hEGF is pivotal for achieving the most efficacious treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16727","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:36:21Z","timestamp":1735018581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Study of Intradermal Injection of Non\u2010Crosslinked Sodium Hyaluronate Combined With Human Epidermal Growth Factor in the Treatment of Skin Barrier Injury in Plateau Area"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9872-4412","authenticated-orcid":false,"given":"Ao","family":"He","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Affiliated Calmette Hospital of Kunming Medical University  Kunming 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