{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:56:56Z","timestamp":1792717016069,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010inflammatory hyperpigmentation (PIHP) predominantly affects patients with melanin\u2010rich skin, significantly impacting them psychosocially due to more frequent and severe pigmentary changes. In this study, the efficacy of a novel depigmenting agent 2\u2010mercaptonicotinoyl glycine (Melasyl) in a dermocosmetic (DC) serum formulation is assessed as a stand\u2010alone treatment of PIHP without sunscreen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Thirty\u2010two Mauritian subjects aged 18\u201350\u2009years of phototype IV\u2013VI presenting mild acne (GEA2) and moderate to severe PIHP (PAHPI &gt;\u200910) participated in this study. Subjects applied the DC serum twice a day on the whole face for 3\u2009months. Efficacy was assessed through PAHPI score, mean darkness of lesions (0\u20138 scores), and colorimetric measurements at D0, D14, D28, D56, and D84. Self\u2010perceived efficacy, tolerability, stigmatization, cosmeticity, and satisfaction were also gathered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant decrease of 15.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in PAHPI score was reported at D84. The PAHPI score showed marked changes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in pigmentation intensity at D56. Visible significant changes in mean darkness were observed from D28, with a 25.1% decrease at D84. A significant brightening effect was observed in both the spots and adjacent areas, with their mean ITA values increasingly converging toward the ITA of the non\u2010treated, non\u2010exposed zone. This effect was more pronounced in the spots, which showed a significant increase from \u221234.1 to \u221214.2 by D14. Instrumental measurements revealed a 60% reduction in spot color intensity at D84 compared to the adjacent area Delta\n                      <jats:italic>E<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), significant from D14. Subjects reported self\u2010perceived improvements in appearance and well\u2010being that matched clinical results, enhancing their quality of life and satisfaction. The product was reported as very well tolerated by the subjects after 84\u2009days of usage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrated the efficacy and tolerability of the serum in the treatment of post acne PIHP. Good clinical results are confirmed by the objective measurement of the ITA and Delta\n                      <jats:italic>E<\/jats:italic>\n                      . Cosmeticity was excellent and will help observance in real life. The reduction of the stigmatization score illustrates the impact of PIHP and its improvement over time. These results can be considered highly encouraging with the new serum, as in real life, its use in combination with a UVA\/visible light filtration sunscreen would probably increase patients benefit.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16735","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T12:38:51Z","timestamp":1735216731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of a 2\u2010\n                    <scp>MNG<\/scp>\n                    \u2010Containing Depigmenting Serum in the Treatment of Post\u2010Inflammatory Hyperpigmentation"],"prefix":"10.1111","volume":"24","author":[{"given":"Ann Laure","family":"Demessant\u2010Flavigny","sequence":"first","affiliation":[{"name":"La Roche Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitanjali","family":"Petkar","sequence":"additional","affiliation":[{"name":"Centre International d\u00e9veloppement Pharmaceutique, CIDP  Phoenix Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Jodun","sequence":"additional","affiliation":[{"name":"Centre International d\u00e9veloppement Pharmaceutique, CIDP  Phoenix Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u00e9na\u00eblle","family":"Le Dantec","sequence":"additional","affiliation":[{"name":"La Roche Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Le Floc'h","sequence":"additional","affiliation":[{"name":"La Roche Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-4261","authenticated-orcid":false,"given":"Delphine","family":"Kerob","sequence":"additional","affiliation":[{"name":"La Roche Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2019.04.180212"},{"key":"e_1_2_12_3_1","volume-title":"Acne Vulgaris","author":"Sutaria A. 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