{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:42:41Z","timestamp":1773769361959,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin aging is inevitable. Wrinkles, skin texture abnormalities, senile hyperpigmentation, loss of skin tone, dryness, atrophy, and telangiectasias represent some of the hallmarks of aged skin. Skin rejuvenation can be addressed by topical therapies, such as topical retinoids and antioxidants or physical modalities with energy\u2010based devices, all providing acceptable outcomes. In this case series, we aimed to test the rejuvenating potential of the combination of cysteamine (a naturally occurring antioxidant) and isobionicamide (a derivative of the anti\u2010aging molecule niacinamide) applied topically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Healthy male and female patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20097) aged between 25 and 70\u2009years and having Fitzpatrick skin types I\u2013VI were recruited. Topical application of a cysteamine\u2010isobionicamide formula was done once daily. Treatment lasted for 16\u2009weeks. Clinical high\u2010resolution photos were acquired using LifeViz 3D at recruitment and after 16\u2009weeks. Blinded dermatological examinations and scoring were performed. Self\u2010assessment and quality of life (QoL) questionnaires were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical photos showed improvement in skin luminosity, increased evenness of skin tone, and reduction of fine wrinkles as well as hyperpigmentation. Patients as well as clinical investigators blinded to the chronology of photos observed the improvements in skin texture, luminosity, and radiance, the brightening of the dark spots, as well as the reduction of both number and volume of wrinkles after 16\u2009weeks of daily application. Furthermore, a significant improvement in patients' quality of life was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case series represents the first evidence that topical application of cysteamine isobionic\u2010amide complex could be considered as a safe and effective option in the reversal of skin photoaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16743","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:22:48Z","timestamp":1737012168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Series With Cysteamine\u2013Isobionicamide Complex: Clues for Skin\u2010Rejuvenating Activity"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5357-9347","authenticated-orcid":false,"given":"Lesley","family":"Clark\u2010Loeser","sequence":"first","affiliation":[{"name":"Precision Skin Institute  Davie Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-0736","authenticated-orcid":false,"given":"Riccardo","family":"Sfriso","sequence":"additional","affiliation":[{"name":"Scientis SA  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9640-3017","authenticated-orcid":false,"given":"Laure","family":"Dirlewanger","sequence":"additional","affiliation":[{"name":"Scientis SA  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5996-1035","authenticated-orcid":false,"given":"Behrooz","family":"Kasraee","sequence":"additional","affiliation":[{"name":"Scientis SA  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12145"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/930164"},{"issue":"6","key":"e_1_2_11_4_1","first-page":"s104","article-title":"The Future of Non\u2010Invasive Rejuvenation Technology: Devices","volume":"16","author":"Gold M. 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