{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:42:17Z","timestamp":1773769337921,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873347"],"award-info":[{"award-number":["81873347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea is a prevalent inflammatory skin condition, but its molecular mechanisms and treatment responses remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to investigate the molecular mechanisms underlying rosacea and explore drug response through transcriptomic analysis and in\u00a0vitro experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>We performed high\u2010throughput RNA sequencing to analyze gene expression patterns in rosacea patients. In\u00a0vitro experiments, including RT\u2010qPCR, Western blot, ELISA, scratch, and Transwell assays, were used to evaluate gene and protein expression and cell behavior in HaCaT cells under simulated rosacea conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Transcriptomic analysis revealed significantly elevated expression of inflammatory\u2010related genes in rosacea patients. In\u00a0vitro, HaCaT cells exhibited enhanced proliferation and migration abilities, accompanied by increased expression of pro\u2010inflammatory genes and proteins. Specifically, Toll\u2010like receptor 2 (TLR2) and S100A9 proteins were upregulated, potentially promoting these processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study elucidates the molecular mechanisms of rosacea, highlighting the role of inflammatory pathways and altered cell behavior in the disease. TLR2 and S100A9 may contribute to disease progression, offering potential targets for future therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16753","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T01:48:28Z","timestamp":1737078508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Molecular Mechanisms of Rosacea: Insights From Transcriptomics and In\u00a0Vitro Experiments"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5343-8698","authenticated-orcid":false,"given":"Luzhu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine The Affiliated Hospital of Hubei University of Chinese Medicine  Wuhan 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