{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:41:56Z","timestamp":1773769316146,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Botulinum toxin (BTX) is globally the most common aesthetic procedure. Its usage has expanded beyond facial treatments to therapeutic areas, including managing scars and postsurgical deformities. Breast cancer survivors often face significant deformities and asymmetry during recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study systematically reviewed literature from the past 4\u2009years on botulinum toxin applications in breast cancer survivors and presented a case report of a patient treated with Incobotulinum toxin (IncoBonTA; Xeomin, Merz Pharmaceuticals GmbH, Frankfurt, Germany) for left breast deformity postchemotherapy and radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA guidelines, a systematic search was conducted on PubMed and Scopus using keywords: \u201cbotulinum toxin,\u201d \u201cbreast cancer,\u201d and \u201cbreast asymmetry,\u201d identifying relevant literature from 2020 to 2024. Five full\u2010text articles were included. Additionally, a 2024 case report of a patient with significant breast asymmetry postsurgery and radiotherapy was published.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The literature review indicated botulinum toxin's primary uses in breast cancer include pain management, upper limb impairment, postsurgical scars, and capsular contracture. Although some benefits were reported, further research is needed. In the case report, the patient was treated in one session with IncoBonTA at two different dilutions based on contracture severity without complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The review showed promising advances in using botulinum toxin for deformities secondary to oncological treatment in breast cancer patients. The therapy was administered to a 53\u2010year\u2010old patient, resulting in significant aesthetic improvement, especially at the nipple and areola, suggesting that it was a viable option for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16754","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T02:25:49Z","timestamp":1735957549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intradermal Incobotulinum Toxin A for Postbreast Cancer Treatment Asymmetry: A Literature Review and Case Report"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7088-1905","authenticated-orcid":false,"given":"Alejandra","family":"Bugallo","sequence":"first","affiliation":[{"name":"Dermatologist Beauty Care Clinic  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-3440","authenticated-orcid":false,"given":"Luis Alberto","family":"Parra","sequence":"additional","affiliation":[{"name":"Aesthetics Physician Sociedad Internacional de Rejuvenecimiento Facial no Quirurgico (SIRF)  Barranquilla Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1162-6914","authenticated-orcid":false,"given":"Andreina Martinez","family":"Amado","sequence":"additional","affiliation":[{"name":"Aesthetics Physician Clinical Research \u2013 Encefalo  Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"De la Fuente","sequence":"additional","affiliation":[{"name":"Dermatologist at Levels Clinic in Mexico D.F  Mexico Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evalicia","family":"Mur\u00faa","sequence":"additional","affiliation":[{"name":"Ophthalmologist \u2013 Oculoplastic Surgery Dra Evalicia Mur\u00faa Clinic  Mexico, D.F Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Garc\u00e9s","sequence":"additional","affiliation":[{"name":"Plastic Surgery Regenera Skin  Barranquilla Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-1328","authenticated-orcid":false,"given":"Andrea Marcela","family":"Parra","sequence":"additional","affiliation":[{"name":"Ophthalmologist \u2013 Oculoplastic Surgery Sociedad Internacional de Rejuvenecimiento Facial no Quirurgico (SIRF)  Barranquilla Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cancer \u2013 World Health Organization (WHO) \u201cBreast Cancer \u201d(2023) https:\/\/www.paho.org\/en\/topics\/breast\u2010cancer."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1001019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5935\/2177-1235.2021RBCP0103"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004770"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004348"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004343"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003372"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13175"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15110636"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-023-01435-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000006144"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.012658"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.2.209"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08830-7"},{"issue":"3","key":"e_1_2_10_18_1","first-page":"Cd006499","article-title":"Botulinum Toxin for the Treatment of Strabismus","volume":"3","author":"Rowe F. 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