{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:17:41Z","timestamp":1791839861364,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exosomes are nanoscale vesicles derived from various cell types and tissues that have many potential applications, generating great interest from researchers. One particularly intriguing application of exosomes is their use as a direct therapeutic for aesthetic indications. Several studies and case reports have explored the impact of exosomes for numerous cosmetic concerns but a consensus on the outcomes of these studies has not been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In this review, we summarize the proposed mechanism of action, application, and efficacy of treatments with exosomes for alopecia and hair rejuvenation, facial rejuvenation, hyperpigmentation, and scarring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive literature review on the use of exosomes for the treatment of alopecia and hair rejuvenation, facial rejuvenation, hyperpigmentation, and scarring. Additionally, several practical clinical cases where exosomes were applied for these indications were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The general consensus from the literature review showed that the early evidence supports the efficacy of exosomes for the treatment of alopecia, facial rejuvenation, hyperpigmentation, and scarring. The clinical cases included demonstrated promising improvements in the patients that received treatment. Several limitations regarding the lack of standardization in the production and application of exosomes may limit their current use until more studies are conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exosomes may serve as a potentially beneficial therapeutic option for several aesthetic dermatologic indications but further investigation is required to fully characterize the scope of their application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16766","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T04:54:43Z","timestamp":1736225683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Exosomes for Aesthetic Dermatology: A Comprehensive Literature Review and Update"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-9887","authenticated-orcid":false,"given":"Milaan","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Dukharan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansas City University \u2013 GME Consortium\/Advanced Dermatology and Cosmetic Surgery  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Broughton","sequence":"additional","affiliation":[{"name":"School of Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Stegura","sequence":"additional","affiliation":[{"name":"School of Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Schur","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine  Bradenton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Samman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Garnet Health Medical Center  Middletown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Garcia\u2010Meraz","sequence":"additional","affiliation":[{"name":"Instituto Panamericano de Profesionales Cient\u00edficos \u2013 Sociedad Mexicana Cient\u00edfica de Medicina Est\u00e9tica  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jona Louise D.","family":"Macaraeg\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Belo Medical Group  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