{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:59:53Z","timestamp":1788296393357,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Topical retinoids, while renowned for their efficacy in treating acne vulgaris, are often hampered by inter\u2010individual variability in tolerability. This challenge, primarily driven by side effects like erythema, scaling, and dryness, significantly impacts patient adherence and, ultimately, treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This prospective, multi\u2010center, observational study investigated the novel role of a specific dermocosmetic regimen as adjunctive therapy, focusing on its ability to mitigate retinoid\u2010induced side effects and enhance the overall tolerability of acne treatment regimens in a Korean population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We enrolled 304 patients receiving conventional acne therapies and integrated a standardized dermocosmetic regimen (foaming facial wash and moisturizer) for 12\u2009weeks. Our primary endpoint assessed changes in skin sensitivity scores in both retinoid and non\u2010retinoid users. We incorporated a patient\u2010reported outcome measure evaluating acne's impact on quality of life across different facial areas as a secondary endpoint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results revealed a significant improvement in skin sensitivity across both patient groups, effectively mitigating the anticipated heightened sensitivity in retinoid users. This finding suggests that dermocosmetics may hold the key to unlocking consistent, age\u2010independent tolerance to retinoid therapy. Furthermore, we observed a compelling correlation between improvements in cheek acne and enhanced quality of life, highlighting the profound psychological impact of this specific facial area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study pioneers a new understanding of holistic acne management, emphasizing the synergistic potential of dermocosmetics in enhancing treatment adherence, improving long\u2010term outcomes, and ultimately transforming patients' lives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16772","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T04:40:26Z","timestamp":1736138426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Enhanced Tolerability and Improved Outcomes in Acne Management: A Real\u2010World Study of Dermocosmetic Adjunctive Therapy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-7340","authenticated-orcid":false,"given":"Dong Hye","family":"Suh","sequence":"first","affiliation":[{"name":"ArumdaunNara Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-0510","authenticated-orcid":false,"given":"Tae\u2010Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyung Hee University College of Medicine Kyung Hee University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7133-3895","authenticated-orcid":false,"given":"Sang Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"ArumdaunNara Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6754-8925","authenticated-orcid":false,"given":"Su Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Statistics Support Part Medical Science Research Institute, Kyung Hee University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsun","family":"Baek","sequence":"additional","affiliation":[{"name":"Medical Affairs, La Roche Posay, Loreal Dermatological Beauty L'Or\u00e9al Korea Ltd.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-7931","authenticated-orcid":false,"given":"Min Kyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyung Hee University College of Medicine Kyung Hee University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.190102"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S158129"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20104362.2000.00907.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5551774"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010017\u20100185\u20102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S182317"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16120"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.23.094"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600717704"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14000"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.S47324"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.5393"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13540"},{"key":"e_1_2_10_14_2","doi-asserted-by":"crossref","unstructured":"Erratum in:Skin Research and Technology30 no.7(2024):e13866 https:\/\/doi.org\/10.1111\/srt.13866.","DOI":"10.1111\/srt.13866"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1628173"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0356"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.56596"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2021.03.002"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:37:29Z","timestamp":1773758249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jocd.16772"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16772","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16772"}}