{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:29:02Z","timestamp":1788805742667,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Hair thinning in men is a prevalent issue for which treatment oftentimes consists of a multi\u2010modal approach. Targeting key root causes of hair thinning, such as hormones, stress, and metabolism through vitamins, minerals, and botanicals, has been shown to be effective in improving hair growth and quality in women. This approach could also be effective in improving hair growth and quality in men with thinning hair.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n This study investigates the safety and efficacy of a nutraceutical in improving hair growth and quality in men with thinning hair.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a 6\u2010month multi\u2010center, double\u2010blind, randomized, placebo\u2010controlled trial. Men aged 21\u201361\u2009years old with confirmed hair thinning were included. Subjects were randomized to receive the oral supplement or placebo. The study end points included changes in blinded Global Investigator Ratings for hair growth and quality, the Men's Hair Growth Questionnaire (MHGQ), and changes in the Arizona Sexual Experience Scale (ASEX) in the active group compared to baseline and placebo.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Daily intake of the nutraceutical resulted in significantly more subjects in the active group compared to the placebo rated as improved for hair growth and quality in the blinded investigator global assessments. Overall changes and responses to the MHGQ also corroborated blinded investigator ratings. There were no trends in either treatment group for changes in sexual function on the ASEX questionnaire, and the supplement was well tolerated.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Ingestion of a nutraceutical targeting key root causes of male hair thinning significantly improves hair growth and quality in men with no changes in sexual function.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.16778","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T03:02:33Z","timestamp":1736132553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Randomized, Double\u2010Blind, Placebo\u2010Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair"],"prefix":"10.1111","volume":"24","author":[{"given":"Neal","family":"Bhatia","sequence":"first","affiliation":[{"name":"Therapeutics Clinical Research San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-2717","authenticated-orcid":false,"given":"Glynis","family":"Ablon","sequence":"additional","affiliation":[{"name":"Ablon Skin Institute Research Center Manhattan Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4349-0129","authenticated-orcid":false,"given":"Patricia K.","family":"Farris","sequence":"additional","affiliation":[{"name":"Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5051-3697","authenticated-orcid":false,"given":"Adina","family":"Hazan","sequence":"additional","affiliation":[{"name":"Nutraceutical Wellness Inc. New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Raymond","sequence":"additional","affiliation":[{"name":"Nutraceutical Wellness Inc. New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"American Hair Loss Association \u201cMen's Hair Loss \u201d2024 accessed August 27 2024 https:\/\/www.americanhairloss.org\/mens\u2010hair\u2010loss\/."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010023\u201001880\u2010x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.8137"},{"issue":"11","key":"e_1_2_11_5_1","first-page":"s141","article-title":"A Novel Multi\u2010Targeting Approach to Treating Hair Loss, Using Standardized Nutraceuticals","volume":"16","author":"Farris P. K.","year":"2017","journal-title":"Journal of Drugs in Dermatology"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"21","article-title":"A Prospective Six\u2010Month Single\u2010Blind Study Evaluating Changes in Hair Growth and Quality Using a Nutraceutical Supplement in Men and Women of Diverse Ethnicities","volume":"15","author":"Stephens T. J.","year":"2022","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5701"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"558","article-title":"A Six\u2010Month, Randomized, Double\u2010Blind, Placebo\u2010Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self\u2010Perceived Thinning Hair","volume":"17","author":"Ablon G.","year":"2018","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.8421"},{"issue":"11","key":"e_1_2_11_10_1","first-page":"s135","article-title":"New Insight Into the Pathophysiology of Hair Loss Trigger a Paradigm Shift in the Treatment Approach","volume":"16","author":"Sadick N. 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