{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:58:52Z","timestamp":1787968732355,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Rosacea is a common skin condition that affects the physical and mental health of the patient. The objective of this study was to evaluate the efficacy and safety of oxymetazoline 1% cream, a specific \u03b11A\u2010adrenoceptor agonist, for the treatment of mild to moderate facial rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In phase II of the before\u2013after study, 15 patients with mild to moderate rosacea were enrolled and treated with oxymetazoline 1% cream twice daily for 4\u2009weeks. The clinician's erythema assessment (CEA) and patient's self\u2010assessment (PSA), as well as the skin biometric parameters (transepidermal water loss, sebum, stratum corneum hydration, temperature, erythema, melanin, and pH), dermal and epidermal thickness and echo\u2010density, and capillaroscopic pattern were assessed and compared before and after treatment. <jats:italic>p<\/jats:italic>\u2010Value\u2009&lt;\u20090.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CEA and PSA indexes decreased significantly 2 and 4\u2009weeks after the treatment (<jats:italic>p<\/jats:italic>\u2010value: 0.001). The erythema index also decreased significantly in both 2\u2009weeks (<jats:italic>p<\/jats:italic>\u2010value: 0.001) and 4\u2009weeks (<jats:italic>p<\/jats:italic>\u2010value: 0.001) after the treatment. The capillaroscopic pattern of lesions showed a decrease in telangiectasia and a reddish background of skin. No side effects of treatment were experienced by any of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oxymetazoline 1% cream was safe and effective in treating mild to moderate facial rosacea. The reduction in the skin's vascularity was also objectively confirmed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16782","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T23:33:57Z","timestamp":1743550437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of Oxymetazoline 1% Cream for the Treatment of Mild to Moderate Facial Rosacea"],"prefix":"10.1111","volume":"24","author":[{"given":"Fatemeh","family":"Sajdeh","sequence":"first","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-429X","authenticated-orcid":false,"given":"Aniseh","family":"Samadi","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Naeimifar","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraneh","family":"Yazdanparast","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Amiri","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kassir","sequence":"additional","affiliation":[{"name":"Worldwide Laser Institute  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Firooz","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"},{"name":"Clinical Trial Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-6686","authenticated-orcid":false,"given":"Saman Ahmad","family":"Nasrollahi","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-015-0077-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18420"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15122"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16537.1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13143"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"32","article-title":"Topical Oxymetazoline Hydrochloride Cream 1% for the Treatment of Persistent Facial Erythema of Rosacea in Adults: A Comprehensive Review of Current Evidence","volume":"14","author":"Del Rosso J. Q.","year":"2021","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S126850"},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Emerging Topical Drugs for the Treatment of Rosacea","volume":"26","author":"Dall'Oglio F.","year":"2021","journal-title":"Expert Opinion on Emerging Drugs"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JDN.0000000000000564"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"213","article-title":"Clinical Pharmacokinetics of Oxymetazoline Cream Following Topical Facial Administration for the Treatment of Erythema Associated With Rosacea","volume":"17","author":"Kuang A. 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