{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:46:44Z","timestamp":1789829204847,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Doxepin (DX) is used orally to relieve itching but can cause side effects like blurred vision, dry mouth, and drowsiness due to its antimuscarinic effect. To reduce these adverse effects and improve skin permeation, DX is being developed in topical formulations. This study aims to improve DX skin absorption by developing a microemulsion (ME) formulation (ME\u2010DX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and Materials<\/jats:title>\n                    <jats:p>ME formulations containing 5% DX were prepared using the phase diagram method with a mixture of essential oil (oleic acid), surfactant (Tween 80 and Labrazol), and cosurfactant (propylene glycol or PG). The physicochemical properties of these formulations were assessed to improve the topical application of DX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ME droplet sizes ranged from 9.8 to 61.6 nm, with viscosities between 114 and 239 cps. Studies showed a significant correlation between DX release percentages and viscosity. ME\u2010DX\u20102 released 46.51% of the drug after 24 h. Selected ME\u2010DX formulations demonstrated Weibull, Log Wagner, and zero\u2010order release kinetics, and improved skin permeability. ME\u2010DX\u20108 exhibited an eightfold increase in\n                      <jats:italic>J<\/jats:italic>\n                      ss and\n                      <jats:italic>P<\/jats:italic>\n                      parameters compared to the control group. MEs maintained 99.9% of DX after 6\u2009months without color changes or phase separation, indicating long\u2010term stability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This research demonstrates that altering the content and composition of MEs can change the physicochemical properties and permeability characteristics of DX when introduced into rats. Additionally, ME formulation shows promise as an effective vehicle for topical DX delivery in atopic dermatitis treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16786","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T01:01:02Z","timestamp":1737507662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Design, Preparation, and Ex\u00a0Vivo Skin Permeation of Doxepin Microemulsion System for Topical Delivery"],"prefix":"10.1111","volume":"24","author":[{"given":"Hossein Heidari","family":"Kaydan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eskandar","family":"Moghimipour","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Ahvaz 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