{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:51:05Z","timestamp":1788918665294,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The nose, eyebrow, and forehead are critical elements of the T\u2010zone, vital for enhancing facial three\u2010dimensionality. Many Asians seek a more contoured and sculpted facial appearance by T\u2010zone augmentation. The novel poly\u2010L\u2010lactic acid microsphere and hyaluronic acid suspension (PLLA\u2010b\u2010PEG\/HA) has proven to be a safe and effective dermal filler, making it an appealing choice for individuals aiming for T\u2010zone augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To retrospectively assess the efficacy and safety of PLLA\u2010b\u2010PEG\/HA injection into the T\u2010zone for aesthetic enhancement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen participants were included in this study. A comprehensive clinical evaluation was performed, including measurements of total facial convexity angle and radix height, the FACE\u2010Q scales for satisfaction with the nose, forehead, and eyebrows, the Global Aesthetic Improvement Scale (GAIS), and a 7\u2010item satisfaction scale. Tissue in the peri\u2010eyebrow area was examined 12\u2009months posttreatment for comparison with normal tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant increases in radix height and total facial convexity angle were observed at each follow\u2010up visit (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). FACE\u2010Q scores also showed significant improvements from baseline in the eyebrows, forehead, and nose at each posttreatment visit (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The GAIS improvement rate remained high, with 80.00% reported by participants and 86.67% by blinded evaluators 12\u2009months after treatment. The satisfaction rate was 73.3% at this time interval. Pathological examinations demonstrated newly formed collagen fibers and microvessels, with no abnormal pathological structure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The PLLA\u2010b\u2010PEG\/HA demonstrates efficacy in enhancing the T\u2010zone (nose, eyebrow, and forehead) with a favorable safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70003","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T08:41:39Z","timestamp":1742719299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Enhancing Facial Projection: Efficacy and Safety of a Novel Filler Combining Cross\u2010Linked Sodium Hyaluronate Gel With Poly\u2010L\u2010Lactic Acid\u2010b\u2010<scp>PEG<\/scp> Microspheres for T\u2010Zone Augmentation"],"prefix":"10.1111","volume":"24","author":[{"given":"Shiwei","family":"Wang","sequence":"first","affiliation":[{"name":"Medical Department Imeik Technology Development Co. Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxian","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Chongqing Xingchen Plastic Surgery Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Ningbo Jia He Plastic Surgery Hospital  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyan","family":"Zou","sequence":"additional","affiliation":[{"name":"Medical Department Imeik Technology Development Co. Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Second Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqun","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Second Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialun","family":"Li","sequence":"additional","affiliation":[{"name":"Plastic Surgery Pikeli Medical Aesthetics  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Department Imeik Technology Development Co. Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Diao","sequence":"additional","affiliation":[{"name":"Medical Department Imeik Technology Development Co. Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9720-0315","authenticated-orcid":false,"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Second Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001706"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245557"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-015-0562-0"},{"issue":"4","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/s-0035-1564817","article-title":"Nasal Analysis and Anatomy: Anthropometric Proportional Assessment in Asians\u2010Aesthetic Balance From Forehead to Chin, Part 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