{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:51:35Z","timestamp":1791496295386,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical diagnosis and staging of vitiligo often rely on the patient's subjective recollection, physician's experience, or clinical evaluation methods. An objective, quantitative diagnostic approach is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study was performed to compare the sensitivity and specificity of different lesion areas and full scanning of lesion areas using reflectance confocal microscopy (RCM) for diagnosis and staging of vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and RCM data of patients diagnosed with vitiligo were collected. RCM data were gathered from three sites of a lesion: the center of the lesion, the margin of the lesion, and the perilesional normal skin. Scoring was conducted for each method, categorizing the results as either the progressive or stable stage of vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sensitivity was significantly lower in the perilesional normal skin than at multiple sites (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The specificity was significantly lower in the center of the lesion and at the margin than at multiple sites and significantly higher in the perilesional normal skin than at multiple sites (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of RCM of different lesion areas of vitiligo showed that the rate of missed diagnosis of the progressive stage was lowest in the center of the lesion and comparable to that of multiple sites. The misdiagnosis rate for the stable stage was lowest in the perilesional normal skin, significantly differing from the other sites. Overall, scanning multiple sites yielded the most accurate results, offering flexibility in selection according to the patient's compliance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70006","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T07:33:27Z","timestamp":1738913607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sensitivity and Specificity Analysis of Different Lesion Areas of Vitiligo by Reflectance Confocal Microscopy"],"prefix":"10.1111","volume":"24","author":[{"given":"Jiyuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology Wuhan No. 1 Hospital  Wuhan China"},{"name":"Hubei Province and key Laboratory of Skin Infection and Immunity  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5737-0519","authenticated-orcid":false,"given":"Miaomiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wuhan No. 1 Hospital  Wuhan China"},{"name":"Hubei University of Chinese Medicine  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijia","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wuhan No. 1 Hospital  Wuhan China"},{"name":"Hubei University of Chinese Medicine  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wuhan No. 1 Hospital  Wuhan China"},{"name":"Hubei Province and key Laboratory of Skin Infection and Immunity  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wuhan No. 1 Hospital  Wuhan China"},{"name":"Hubei Province and key Laboratory of Skin Infection and Immunity  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wuhan No. 1 Hospital  Wuhan China"},{"name":"Hubei Province and key Laboratory of Skin Infection and Immunity  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"562","article-title":"Diagnostic Analysis of Reflectance Confocal Microscopy Features for Vitiligo Staging","volume":"41","author":"Changhong W.","year":"2019","journal-title":"Dermatology and Venereology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14260"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010017\u20108622\u20107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17150"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1294919"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.27134\/d.cnki.ghbzc.2022.000202"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13084"},{"issue":"5","key":"e_1_2_10_10_1","first-page":"471","article-title":"Comparison of Chinese and International Guidelines and Consensus for the Diagnosis and Treatmentof Vitiligo","volume":"56","author":"Weixue J. 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A.","year":"2023","journal-title":"Chinese Journal of Dermatology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02275.x"},{"issue":"11","key":"e_1_2_10_12_1","first-page":"147","article-title":"Application of Skin CT in Staging of Vitiligo","volume":"16","author":"Wang R.","year":"2018","journal-title":"Chinese Journal of CT and MRI"},{"issue":"6","key":"e_1_2_10_13_1","first-page":"373","article-title":"Treatment Standards for Melasma and Vitiligo (2010 Version)","volume":"43","author":"Dermatology C O T a W M","year":"2010","journal-title":"Chinese Journal of Dermatology"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"105","article-title":"Consensus on the Diagnosis and Treatment of Vitiligo (2021 Version)","volume":"54","author":"Dermatology C O T a W M","year":"2021","journal-title":"Chinese Journal of Dermatology"},{"issue":"4","key":"e_1_2_10_15_1","first-page":"247","article-title":"Pigmentary Disease Group of the Professional Committee of Dermatological and Venereal Diseases of the Chinese Society of Integrative Medicine. Consensus on the Diagnosis and Treatment of Vitiligo (2018 Version)","volume":"51","author":"Pigmentary Disease Group","year":"2018","journal-title":"Chinese Journal of Dermatology"},{"issue":"2","key":"e_1_2_10_16_1","first-page":"90","article-title":"Exploration of the Application of Reflectance Confocal Microscopy Features for the Staging of Vitiligo","volume":"25","author":"Minghua Y.","year":"2018","journal-title":"Journal of Dermatological and Venereal Disease Diagnosis and Treatment"},{"issue":"6","key":"e_1_2_10_17_1","first-page":"404","article-title":"Vitiligo Staging Based on Clinical and Skin Computed Tomography Features","volume":"48","author":"Tao L. I. 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