{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:51:37Z","timestamp":1791496297363,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin hyperpigmentation is a dermatological concern for pigmented skin phototypes. Despite availability of multiple treatment options, hyperpigmentation management continues to be a challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Efficacy and safety assessment of the skincare regimen [topical formulation of trihydroxybenzoic acid glucoside 10% (THBG) and \u03b1\u2010arbutin 2% (twice\u2010daily)\u2009+\u2009sunscreen (once daily)] in Indian females with pigmentary spots (facial dark spots or melasma).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, open\u2010label, single\u2010arm, interventional study was conducted in Indian females (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009124), aged 18\u201345\u2009years, having FitzPatrick skin type III\u2013IV, dull skin, and facial dark spots or melasma. Efficacy of 90\u2010day skincare regimen was evaluated using mexameter, modified melasma area and severity index (mMASI) score, cross\u2010polarized light photography, chromameter, and color\u2013luminosity\u2013brightness\u2013transparency (CLBT) technique. Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test (paired data) was used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In efficacy analysis [modified intention\u2010to\u2010treat (mITT) population], 120 subjects were included. Melanin content of pigmentary spots (on mexametry) significantly reduced (\u221216.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at Day 90 versus baseline. Significant reduction in severity of melasma was observed (\u221218.4% in mMASI score) at Day 90. Significant improvement in \u0394Eab (\u22128.7%) (change in color difference between pigmentary spot and normal skin) on cross\u2010polarized photographs, in skin\u2010brightening parameters\n                      <jats:italic>L<\/jats:italic>\n                      * (relative brightness\/lightness) (\u22122.7%), ITA\u00b0 (individual typology angle) (\u221237.7%), and \u0394\n                      <jats:italic>E<\/jats:italic>\n                      * (skin\u2010tone evenness) (\u221219.0%) using chromameter. Significant improvement in skin radiance was observed in CLBT parameters, color (pink: 32.8%, yellow: \u20135.5%, and olive:\u2009\u22127.8%), luminosity (6.0%), brightness (4.6%), and transparency (0.2%). Regimen did not cause itching, burning, or irritation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Skincare regime of 10% THBG and 2% \u03b1\u2010arbutin along with sunscreen was effective in reducing pigmentary spots (dark spots and melasma) and was well tolerated in Indian women.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Clinical Trial Registry of India (CTRI Reg. No. CTRI\/2021\/11\/038345; date: 30\/11\/2021)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70017","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T01:19:06Z","timestamp":1739409546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of a Topical Formulation Containing Trihydroxybenzoic Acid Glucoside and \u03b1\u2010Arbutin, Applied Along With a Sunscreen: A Noncomparative, Prospective, Interventional Study in Indian Females With Facial Melasma or Dark Spots"],"prefix":"10.1111","volume":"24","author":[{"given":"Mukesh","family":"Gabhane","sequence":"first","affiliation":[{"name":"Ex\u2010Employee, Medical Affairs Sun Pharma Laboratories Limited  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raji","family":"Patil","sequence":"additional","affiliation":[{"name":"Dermatologist Mascot Spincontrol India Pvt. Ltd.  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Dharmadhikari","sequence":"additional","affiliation":[{"name":"Medical Affairs Sun Pharma Laboratories Limited  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyank","family":"Shah","sequence":"additional","affiliation":[{"name":"Ex\u2010Employee, Medical Affairs Sun Pharma Laboratories Limited  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Khandhedia","sequence":"additional","affiliation":[{"name":"Medical Affairs Sun Pharma Laboratories Limited  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyog","family":"Mehta","sequence":"additional","affiliation":[{"name":"Medical Affairs Sun Pharma Laboratories Limited  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518826"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.190103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2349-5847.135429"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.140290"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.84722"},{"issue":"6","key":"e_1_2_11_7_1","first-page":"558","article-title":"Medical Management of Melasma: A Review With Consensus Recommendations by Indian Pigmentary Expert Group","volume":"62","author":"Sarkar R.","year":"2017","journal-title":"Indian Journal of Dermatology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0194-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14541"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.4663"},{"issue":"8","key":"e_1_2_11_11_1","first-page":"13","article-title":"Hyperpigmentation Therapy: A Review","volume":"7","author":"SR D.","year":"2014","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071129"},{"issue":"5","key":"e_1_2_11_13_1","first-page":"337","article-title":"A Novel Cream Formulation Containing Nicotinamide 4%, Arbutin 3%, Bisabolol 1%, and Retinaldehyde 0.05% for Treatment of Epidermal Melasma","volume":"96","author":"Crocco E. 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K.LeGendre B.Kishore X.Ren X.Yu andP.Debevec \u201cEfficient Multispectral Facial Capture With Monochrome Cameras \u201dInACM SIGGRAPH 2018 Posters2018 Aug 12:1\u20132.","DOI":"10.1145\/3230744.3230778"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20766"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13741"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:44:07Z","timestamp":1791495847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/jocd.70017"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70017","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70017"}}