{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:51:32Z","timestamp":1791496292116,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Laser\u2010induced post\u2010inflammatory hyperpigmentation (PIH)is a common adverse reaction in Asian individuals. Dark skin and incorrect laser parameters are common causes, but PIH is often unexpected for patients. Obvious hyperpigmentation can lead to an ugly appearance and severe anxiety. Therefore, a fast and effective treatment for laser\u2010induced PIH is necessary. In this article, we attempted to demonstrate that a low\u2010fluence Q\u2010switch (QS) 1064\u2009nm laser combined with oral tranexamic acid (TXA) is a quick and safe method for the clearance of laser\u2010induced PIH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study, adhering to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)\u00a0guidelines, spanning 2\u2009years (2021\u20132023) was conducted on 23 patients aged between 29 and 58\u2009years. These patients were diagnosed with laser\u2010induced PIH for &lt;\u20093\u2009months. The treatment regimen was a low\u2010fluence QS1064\u2009nm laser combined with oral TXA, oral TXA was first taken, and a low\u2010fluence QS1064 nm laser was used for at least 1\u2009month after the last laser was applied. Three to six laser treatments were subsequently applied. After treatment, the pigment color and patient satisfaction were assessed to evaluate the effectiveness of the treatment options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients were enrolled in the study, the average laser treatments were 4.3\u2009\u00b1\u20090.865 times. The Melasma Area and Severity Index (MASI)\u00a0score decreased from 9.325\u2009\u00b1\u20093.38 before treatment to 5.97\u2009\u00b1\u20092.37. After the first treatment, the MASI score decreased by approximately 40%. Two months after the last treatment, the MASI score decreased to 0.93\u2009\u00b1\u20091.06, and there was a statistically significant difference in the MASI score before and after treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Patient satisfaction scores revealed that 95% of patients were highly or strongly satisfied with the decrease in the intensity of the PIH color, with a moderate response rate of 1 (5%). The patients thought that the pigment removal speed was 75% (15) very fast or fast, 20% (4) moderate, and 5% (1) slow.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study demonstrated the quick and safe removal of laser\u2010induced PIH following treatment with low\u2010fluence QS1064\u2009nm laser combined with oral TXA. Providing such a protocol is indeed one of the primary objectives of this article.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70018","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T19:05:09Z","timestamp":1739214309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low\u2010Fluence Q\u2010Switch 1064\u2009Nm Laser Combined With Oral Tranexamic Acid: A Quicker Treatment for Laser\u2010Induced Postinflammatory Hyperpigmentation"],"prefix":"10.1111","volume":"24","author":[{"given":"Wei","family":"Feng","sequence":"first","affiliation":[{"name":"Center for Plastic and Reconstructive Surgery, Department of Plastic and Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Breast Oncoplastic Surgery, Hunan Cancer Hospital and the Affliated Cancer Hospital of Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S394889"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16287"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23135"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378\u20106323.182806"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12050"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010023\u201000759\u20107"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5622"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2015.1114634"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1187706"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754241265716"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12461"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2011.04385.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16104"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.3.250"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4236\/jcdsa.2012.22014"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2011.01957.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010012\u20109899\u20109"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12060"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1427869"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20102077.172196"},{"issue":"11","key":"e_1_2_11_22_1","first-page":"1118","article-title":"Efficacy of Low Fluence Nd:YAG 1064 Nm Laser for the Treatment of Post\u2010Infammatory Hyperpigmentation in the Axillary Area","volume":"16","author":"Ghannam S.","year":"2017","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14176"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23214"}],"container-title":["Journal of Cosmetic 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