{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:59:25Z","timestamp":1793689165134,"version":"4.5.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop a stable and efficient delivery system for baicalin, a flavonoid with potential antioxidant and antiaging properties, to overcome its limitations in solubility, stability, and skin permeability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baicalin was encapsulated using ATP synthase molecular motor technology into bio\u2010vesicles derived from yeast\/bacillus cell membranes, forming \u201cmotor baicalin\u201d (MB). The liposome baicalin (LB), baicalin raw material (BRM), and bio\u2010vesicles were used for comparison. The stability, transdermal penetration, and antioxidant activity of MB, LB, BRM, and bio\u2010vesicles were evaluated through in\u00a0vitro and in\u00a0vivo tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MB formed a stable core\u2010shell structure, significantly enhancing the water solubility and long\u2010term stability of baicalin. The tests confirmed superior transdermal penetration and antioxidant activity of MB, evidenced by increased expression of SOD, CAT, and GSH\u2010Px enzymes and improved cell proliferation and migration. Clinical trials demonstrated significant reductions in wrinkle depth and improvements in skin elasticity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study presents a promising approach to improving the stability and transdermal delivery of baicalin. MB showcases potent antioxidant and antiaging properties, making it a valuable component in skincare products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70024","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T12:41:14Z","timestamp":1739450474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Transdermal Delivery of Baicalin Based on Bio\u2010Vesicles and Its Efficacy in Antiaging of the Skin"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7795-1375","authenticated-orcid":false,"given":"Liang","family":"Chen","sequence":"first","affiliation":[{"name":"Scientific Research Laboratory Shanghai Le\u2010Surely Biotechnology Co. Ltd  Shanghai China"},{"name":"SASELOMO Research Institute and Biological Laboratory Shanghai Chuanmei Industrial Co. Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fudi","family":"Wang","sequence":"additional","affiliation":[{"name":"Evelab Insight (Singapore) Pte. Ltd  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Hu","sequence":"additional","affiliation":[{"name":"Scientific Research Laboratory Shanghai Le\u2010Surely Biotechnology Co. Ltd  Shanghai China"},{"name":"SASELOMO Research Institute and Biological Laboratory Shanghai Chuanmei Industrial Co. Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihong","family":"Li","sequence":"additional","affiliation":[{"name":"Scientific Research Laboratory Shanghai Le\u2010Surely Biotechnology Co. Ltd  Shanghai China"},{"name":"SASELOMO Research Institute and Biological Laboratory Shanghai Chuanmei Industrial Co. 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