{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:51:50Z","timestamp":1791496310602,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ocular adverse reactions caused by the diffusion of BoNT\u2010A injection are self\u2010limiting, with symptoms ameliorating over time. Thyroid\u2010associated ophthalmopathy (TAO) is an autoimmune disease characterized by symptoms such as exophthalmos, diplopia, and eyelid retraction, which may overlap the side effects of BoNT\u2010A injections. It is crucial to consider other ocular diseases when assessing side effects after BoNT\u2010A injection, particularly in patients with a history of thyroid disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe a complicated case of concurrent malignant exophthalmos and unilateral blepharoptosis following an additional dosage of BoNT\u2010A injection for glabellar wrinkles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient<\/jats:title>\n                    <jats:p>A 58\u2010year\u2010old female patient received BoNT\u2010A injection for glabellar wrinkles. Two weeks later, the patient requested an additional dose of BoNT\u2010A to enhance the effects, receiving an extra 8\u2009units BoNT\u2010A in the brow muscles. Twenty days later, she presented with a ptosis in the left eye, which progressively manifested into symptoms of exophthalmos, uncoordinated movement, blurred vision, and double vision. Ultimately, she was diagnosed with malignant exophthalmos.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The blepharoptosis following BoNT\u2010A injection typically manifests a significant improvement within 1\u20133\u2009months. However, if the symptoms of ptosis persist without evident amelioration and are accompanied by additional ocular discomfort, particularly in patients with thyroid disease, the potential presence of concomitant TAO should be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This report highlights the potential relationship between botulinum toxin and thyroid disease, emphasizing the complexity of complications following cosmetic injections. Clinicians should carefully take the history of a patient, thereby facilitating better identification and management of potential complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70028","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T07:54:46Z","timestamp":1738914886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral Blepharoptosis Combined With Malignant Exophthalmos After Botulinum Toxin Injection to Glabellar Lines: A Case Report"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4258-1743","authenticated-orcid":false,"given":"Junli","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Dermatology Air Force Medical University Air Force Medical Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Air Force Medical University Air Force Medical Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Air Force Medical University Air Force Medical Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Air Force Medical University Air Force Medical Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268\u2010014\u20100077\u20101"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"168","article-title":"Botulinum Toxin Injection for Facial Wrinkles","volume":"90","author":"Small R.","year":"2014","journal-title":"American Family Physician"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjac036"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S202919"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.789473"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1475923"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.17116\/jnevro201611610182\u201084"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2021.12.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010010\u20109410\u20109"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14361"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2024.09.012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000689"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:45:37Z","timestamp":1791495937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/jocd.70028"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70028","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70028"}}