{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:51:52Z","timestamp":1791496312961,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Topical insulin (TI) has been shown to enhance wound healing by promoting re\u2010epithelialization and collagen synthesis. However, there have been limited studies addressing its potential use in treating acne scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the efficacy of combining TI with microneedle fractional radiofrequency (MFR) in the treatment of atrophic acne scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Method<\/jats:title>\n                    <jats:p>A split\u2010face, double\u2010blinded, placebo\u2010controlled trial involved 30 participants with atrophic acne scars. Each side of the participants' face was randomly treated with a combination of MFR and TI or a placebo every 4\u2009weeks for four consecutive sessions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant improvements in scar volume were observed, with statistical significance at week 12 for MFR combined with TI sides (baseline 18.22\u2009\u00b1\u20099.86 vs. 16.20\u2009\u00b1\u20098.58\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and at week 16 for MFR combined with placebo sides (baseline 18.02\u2009\u00b1\u20099.24 vs. 15.28\u2009\u00b1\u20098.21\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The TI sides exhibited a reduction of 46.77%\u2009\u00b1\u200921.33% in Echelle d\u2019 \u00e9valuation clinique des cicatrices d\u2019 acne (ECCA) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001), while the placebo sides showed a reduction of 46.39%\u2009\u00b1\u200920.14% in ECCA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001). There were no significant differences in melanin, and hemoglobin index between the two groups. No hypoglycemic symptoms were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining topical insulin with MFR is safe and could accelerate the early acne scar improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70033","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T12:57:01Z","timestamp":1739969821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Microneedle Fractional Radiofrequency Combined With Topical Insulin for the Treatment of Facial Atrophic Acne Scars: A Split\u2010Face, Double\u2010Blinded, Randomized, Placebo\u2010Controlled Trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1654-9706","authenticated-orcid":false,"given":"Teerapong","family":"Rattananukrom","sequence":"first","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasama","family":"Tejapira","sequence":"additional","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5511-1937","authenticated-orcid":false,"given":"Cherrin","family":"Pomsoong","sequence":"additional","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanisa","family":"Ratanapokasatit","sequence":"additional","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-939X","authenticated-orcid":false,"given":"Vasanop","family":"Vachiramon","sequence":"additional","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/893080"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.47"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2021.11.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S350040"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1601-z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S74411"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.02.015"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S237294"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800415592175"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00792.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b09395"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.152"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15376"},{"key":"e_1_2_11_15_1","unstructured":"R. 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