{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:08:19Z","timestamp":1783570099751,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Botulinum toxin is a widely utilized minimally invasive therapeutic option with minimal downtime and a low risk of serious complications. The long pulse Nd:YAG laser treatment (PIANO) has been utilized in recent years for skin rejuvenation and tightening, body shaping, and transdermal lipolysis through bulk heating of the tissue. The heat\u2010labile bond between the heavy and light chains of botulinum toxin could be affected by laser bulk heating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This case series aims to clinically evaluate the efficacy of botulinum toxin when used in conjunction with PIANO 1064\u2009nm bulk heating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This case series included two patients who underwent standard hyperhidrosis treatment with botulinum toxin and then single\u2010sided concomitant long\u2010pulsed Nd:YAG laser treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The iodine\u2013starch test revealed no differences between the two areas at follow\u2010up visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This small study corroborates the findings of other research indicating that long\u2010pulsed 1064\u2009nm Nd:YAG laser treatment does not affect the efficacy of botulinum toxin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70042","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:23:19Z","timestamp":1741764199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Concomitant Use of Botulinum Toxin and Super Long Nd:<scp>YAG<\/scp> Laser"],"prefix":"10.1111","volume":"24","author":[{"given":"Jernej","family":"Kukovi\u010d","sequence":"first","affiliation":[{"name":"Medilase d.o.o  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-6497","authenticated-orcid":false,"given":"An\u017ee","family":"Zorman","sequence":"additional","affiliation":[{"name":"Medilase d.o.o  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2016.03.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010022\u201000707\u2010x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2017.01.009"},{"issue":"4","key":"e_1_2_8_5_1","first-page":"292","article-title":"Botulinum Toxin for the Treatment of Bruxism","volume":"33","author":"Tinastepe N.","year":"2015","journal-title":"Dermatologic Therapy"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.8.1085"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00122-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.058149"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13010058"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010023\u201003856\u20105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03516-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328249"},{"key":"e_1_2_8_13_1","unstructured":"J.VartanianandS.Dayan \u201cNonablative Facial Skin Tightening \u201dhttps:\/\/emedicine.medscape.com\/article\/844068\u2010overview?form=fpf."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.105567"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2015.1052517"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.2011.1650"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31105"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13976"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002851"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2014.968578"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14023"},{"key":"e_1_2_8_22_1","first-page":"75","article-title":"Photo\u2010Thermal Hormetic Rejuvenation With 1064 nm Nd:YAG PIANO Pulse Laser","volume":"2012","author":"Marini L.","year":"2012","journal-title":"Journal of the Laser and Health Academy"},{"issue":"1","key":"e_1_2_8_23_1","first-page":"26","article-title":"TightSculpting\u00ae: A Complete Minimally Invasive Body Contouring Solution; 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