{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:51:30Z","timestamp":1791496290391,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273538"],"award-info":[{"award-number":["82273538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2508200"],"award-info":[{"award-number":["2023YFC2508200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea is a chronic skin condition that affects millions of people worldwide, and its management continues to pose a significant challenge in dermatology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In this study, we investigated the efficacy and safety of 30% supramolecular salicylic acid (SSA) as a treatment for papulopustular rosacea, with a particular focus on improving skin lesions, reducing persistent erythema, and enhancing skin barrier function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010four patients diagnosed with papulopustular rosacea were randomly divided into an experimental group treated with 30% SSA and a control group receiving a placebo. Clinical outcomes were evaluated based on lesion reduction rates, investigator severity assessment (ISA) scores, VISIA red area scores, and skin barrier, including trans\u2010epidermal water loss (TEWL), sebum levels, stratum corneum hydration, and pH values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 34 patients were collected for both the experimental and control groups, with no statistical differences in age or disease severity between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The effective rate was 68.75% in the experimental group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). After treatment, the ISA score was 1.75\u2009\u00b1\u20090.68 in the experimental group and 2.40\u2009\u00b1\u20090.83 in the control group, indicating significant improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The improvement rate of the VISIA redness score was 25.1% in the experimental group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Among the 17 patients who underwent skin barrier function testing. Skin hydration significantly improved on left cheek (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), right cheek (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and nose (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) after 30% SSA treatment in experimental group. Sebum levels were significantly reduced on both cheeks and forehead (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No statistical differences were observed in other locations. Skin TEWL and pH value showed no changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>30% SSA reduced papules and pustules in rosacea, improved persistent erythema, and enhanced stratum corneum hydration in the 30% SSA\u2010treated group compared to the placebo group. No significant differences were observed in TEWL and skin pH values between the two groups. Our findings suggest that 30% SSA is an effective and safe option for managing papulopustular rosacea, offering a well\u2010tolerated alternative to traditional treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70046","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:28:57Z","timestamp":1739942937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["30% Supramolecular Salicylic Acid Improved Symptoms and Skin Barrier in Papulopustular Rosacea"],"prefix":"10.1111","volume":"24","author":[{"given":"Zihan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical 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