{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:12:34Z","timestamp":1790727154977,"version":"4.1.0"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Porphyria cutanea tarda (PCT) is the most common subtype of porphyria and results from a deficiency of the enzyme uroporphyrinogen decarboxylase. Even after successful treatment, patients can be left with significant scarring, and there is little published data on the safety and efficacy of light\u2010based or laser\u2010based therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This report examines a case of a 47\u2010year\u2010old male with PCT secondary to HCV, treated with a combination of fractionated erbium\u2010doped yttrium\u2010aluminum\u2010garnet (Er:YAG), intense pulsed light (IPL), and carbon dioxide (CO<jats:sub>2<\/jats:sub>) lasers to address significant scarring and residual skin damage. An artificial intelligence model was used to quantify the results of the laser procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After combination laser treatment, the patient exhibited marked improvements in skin texture, reduction in scar visibility, and diminished hyperpigmentation. The artificial intelligence algorithm quantified the laser results and showed improvements in the scores used in the large language model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this patient, customizing a combination of lasers to target different layers of the skin to achieve comprehensive improvement: erbium primarily addressed superficial irregularities and pigmentation, while CO<jats:sub>2<\/jats:sub> promoted deeper collagen remodeling. The use of artificial intelligence to quantify the positive results in this case is in line with the clinical evaluations and photos.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70056","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T09:19:33Z","timestamp":1743499173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of Porphyria Cutanea Tarda Scarring With Combination Laser Treatment and a Pilot Use of Artificial Intelligence to Quantify Laser Results"],"prefix":"10.1111","volume":"24","author":[{"given":"Chelsea E.","family":"Kesty","sequence":"first","affiliation":[{"name":"St. Petersburg Skin and Laser  St. Petersburg Florida USA"},{"name":"Kesty AI  St. Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina R.","family":"Kesty","sequence":"additional","affiliation":[{"name":"St. Petersburg Skin and Laser  St. Petersburg Florida USA"},{"name":"Kesty AI  St. Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-423186"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010017\u20108625\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70050"},{"issue":"8","key":"e_1_2_9_5_1","first-page":"1002","article-title":"Fractional Laser Treatments for Actinic Keratosis and Field Cancerization: A Review of Current Literature","volume":"26","author":"Togsverd\u2010Bo K.","year":"2012","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"issue":"6","key":"e_1_2_9_6_1","first-page":"874","article-title":"Laser and Light Therapy for Acne Scars: A Comprehensive Review","volume":"70","author":"Stratigos A.","year":"2014","journal-title":"Journal of the American Academy of Dermatology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.12.012"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T06:37:21Z","timestamp":1758782241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jocd.70056"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70056","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70056"}}