{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:51:47Z","timestamp":1789588307314,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sporotrichosis is the most prevalent deep mycosis worldwide. The differential diagnosis of its clinical symptoms and histopathological features presents considerable complexity. A thorough understanding of the clinical manifestations and pathological characteristics of sporotrichosis is crucial for its accurate clinical diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study involved a retrospective analysis of cases diagnosed with sporotrichosis at our hospital between April 2017 and April 2019, summarizing their clinical and histopathological characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 323 patients included in this study, a higher prevalence was observed in females. The disease predominantly affected middle\u2010aged and elderly patients, aged between 41 and 67\u2009years, with a higher incidence noted in winter and spring. Among the 323 patients, 170 patients (52.7%) presented with the fixed pattern, 128 (40%) with the lymphatic type, 24 (7%) with the special type, and one patient with the cutaneous\u2010disseminated type. There were no cases of the systemic type. Histopathological findings included diffuse infectious granulomas and inflammatory infiltration, primarily characterized by diffuse and non\u2010specific mixed inflammatory cell infiltration (without granulomas). The granulomas were primarily tuberculoid and purulent, with a lesser occurrence of granulomas exhibiting a three\u2010zone structure, which is typically uncommon. An increase in lymphocytes, plasmacytes, and neutrophils was noted as one of the pathological features of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this region, sporotrichosis was more prevalent among female patients compared to male patients, with the fixed pattern being more common than the lymphatic type. Histopathological manifestations included diffuse infectious granulomas, with inflammatory infiltration primarily characterized by diffuse infiltration and non\u2010specific mixed inflammatory cell infiltration (without granulomas).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70059","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T11:34:19Z","timestamp":1741952059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Presentation and Histopathological Characteristics of Sporotrichosis"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaohong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology The 2nd Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The 2nd Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5907-5410","authenticated-orcid":false,"given":"Jianxun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The 2nd Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed4040122"},{"issue":"5","key":"e_1_2_10_3_1","first-page":"556","article-title":"Clinical Manifestations, Diagnosis and Treatment of Sporotrichosis","volume":"34","author":"Lv S.","year":"2017","journal-title":"Bulletin of Dermatology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv038"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181f5b622"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2013.03.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9198-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04389.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.11.046"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12414"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12346"},{"issue":"4","key":"e_1_2_10_12_1","first-page":"207","article-title":"Clinical Analysis of 316 Eases of Cutaneous Sporotrichosis","volume":"3","author":"Zhang J. D.","year":"2008","journal-title":"Chinese Journal of Mycology"},{"key":"e_1_2_10_13_1","first-page":"289","article-title":"Clinical Analysis of 62 Children With Rototrichosis","author":"Li Y. A.","year":"2003","journal-title":"Bacterial System"},{"key":"e_1_2_10_14_1","unstructured":"T. T.Gao L. Q.Chen andF.Su \u201cA Case of Lymphocutaneous Sporotrichosis Misdiagnosed as Lichen Planus \u201d32(2018) 843\u2013845."},{"issue":"1","key":"e_1_2_10_15_1","first-page":"68","article-title":"A Case of Facial Sporotrichosis Misdiagnosed With Basal Cell Carcinoma","volume":"7","author":"Chen W. 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Sequential Fine and Histologic Studies of the Effect of Bacillus Calmette\u2010Guerin (BCG)","volume":"76","author":"Adams D. O.","year":"1974","journal-title":"American Journal of Pathology"},{"issue":"4","key":"e_1_2_10_22_1","first-page":"203","article-title":"Clinical and Pathological Analysis on 100 Cases of Sporotrichosis","volume":"6","author":"Mei X. L.","year":"2011","journal-title":"Chinese Journal of Mycology"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2019.100908"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:57:07Z","timestamp":1744225027000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jocd.70059"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70059","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70059"}}