{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:34:12Z","timestamp":1790656452386,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Esthetic gynecology addresses the growing demand for treatments covering functional and esthetic concerns of the external genitalia, significantly impacting women's confidence and sexual relationships. While hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) have shown promise in vaginal rejuvenation, data on hybrid filler applications remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This narrative review examines the anatomical, structural, and psychological aspects of labia majora rejuvenation, outlining available treatment options and presenting the authors' experience with a novel HA\/CaHA hybrid filler.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This paper combined a narrative literature review using online databases PubMed and Google Scholar, between 2015 and 2024, with the keywords: \u201clabia majora,\u201d \u201crejuvenation,\u201d \u201caesthetic treatments,\u201d and \u201cfillers\u201d with a case series of two patients treated with a hybrid CaHA\/HA (Radiesse and Belotero Balance Merz Pharmaceuticals GmbH) filler for labia majora volume loss and laxity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010day follow\u2010up evaluations by four experienced physicians revealed substantial improvements in labia majora esthetics. A marked improvement in skin coloration was observed in both patients, with skin appearing more even and less hyperpigmented. Both patients showed noticeable volume restoration, resulting in a fuller appearance of the labia majora. Overall aesthetic improvement was evident, as confirmed by the patients' perception. Patient\u2010reported genital appearance satisfaction, as measured by the GAS score, improved by a mean of 41% (pretreatment mean: 28\/33; posttreatment mean: 15\/33).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These two case reports and a narrative literature review suggest that a combined HA\/CaHA filler may be a safe and effective treatment for labia majora rejuvenation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70074","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:57:22Z","timestamp":1741687042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Labia Majora Rejuvenation With Hybrid Filler: A Narrative Review of the Literature and Report of Two Cases"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1611-781X","authenticated-orcid":false,"given":"Andrea","family":"Acevedo","sequence":"first","affiliation":[{"name":"Aesthetic Medicne University Del Rosario  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Marcela","family":"Parra","sequence":"additional","affiliation":[{"name":"Oculoplastic Surgery\u2010 Ophthalmologist Sociedad Internacional De Rejuvenecimiento Facial no Quir\u00fargico (SIRF)  Barranquilla Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1162-6914","authenticated-orcid":false,"given":"Andreina Martinez","family":"Amado","sequence":"additional","affiliation":[{"name":"Aesthetic Medicine, Clinical Research Universidad De Salamanca  Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9301-2138","authenticated-orcid":false,"given":"Valentina","family":"Dicker","sequence":"additional","affiliation":[{"name":"Aesthetic Medicne University Del Rosario  Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Castelanich","sequence":"additional","affiliation":[{"name":"Dermatologist Sociedad Argentina De Dermatologia  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Velasquez","sequence":"additional","affiliation":[{"name":"Dermatologist Sociedad Colombiana De Dermatolog\u00eda  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-3440","authenticated-orcid":false,"given":"Luis Alberto","family":"Parra","sequence":"additional","affiliation":[{"name":"Aesthetics Medicine Sociedad Internacional De Rejuvenecimiento Facial no Quir\u00fargico (SIRF)  Barranquilla Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"issue":"9","key":"e_1_2_9_2_1","article-title":"A Novel Hyaluronic Acid Filling Technique for Restoring Volume of the Labia Majora","volume":"15","author":"Tarabini F.","year":"2023","journal-title":"Cureus"},{"issue":"8","key":"e_1_2_9_3_1","article-title":"Aesthetic Gynaecology: What Women Want?","volume":"15","author":"Mohammad S.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15484"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjx056"},{"issue":"4","key":"e_1_2_9_6_1","article-title":"Efficacy and Tolerability of a Hyaluronic Acid\u2010Based Extracellular Matrix for Labia Majora Rejuvenation and Augmentation: A Pilot Study","volume":"16","author":"Ayatollahi A.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-023-03617-3"},{"key":"e_1_2_9_8_1","unstructured":"ISAPS (I.S.O.P.S.) \u201cInternational Survey in Aesthetic\/Cosmetic Procedures in 2023 \u201d2023 https:\/\/www.isaps.org\/media\/rxnfqibn\/isaps\u2010global\u2010survey_2023.pdf."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sju020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-020-01980-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000697"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab036"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198409000-00015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001000"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-013-0211-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw083"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2020.01907"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/0167482X.2012.756865"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/07488068241227278"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad173"},{"key":"e_1_2_9_21_1","unstructured":"J. v.Loghem \u201cUse of Calcium Hydroxylapatite for Augmentation of the Labia Majora and Mons Pubis \u201d2017."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010021\u201002479\u2010x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-024-04145-4"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T14:57:54Z","timestamp":1744210674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jocd.70074"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70074","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,27]]},"assertion":[{"value":"2024-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70074"}}