{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:45:11Z","timestamp":1782927911696,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo, a stigmatizing condition characterized by patchy depigmented skin, has an estimated global prevalence of 0.36%. This condition is a risk factor for anxiety, depression, and even suicidal ideation. Hitherto, no network meta\u2010analysis has investigated the relative effect of vitiligo on relevant monotherapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The current study determined the relative effect of monotherapies for vitiligo through network meta\u2010analyses (<jats:styled-content style=\"fixed-case\">NMAs<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The peer\u2010reviewed literature was systematically searched through <jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content> and Scopus; studies that were eligible for quantitative analyses were those that were published in English and had an arm that investigated the effect of a monotherapy on vitiligo at 6\u2009months. Studies of the randomized and observational designs were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The retrieved data were sufficient to analyze networks for phototherapy, Janus kinase inhibitors (<jats:styled-content style=\"fixed-case\">JAKIs<\/jats:styled-content>), calcineurin inhibitors, cyclosporine, corticosteroids, azathioprine, and minocycline. Modalities' effects, in each of the networks, were ranked with the surface under the cumulative <jats:styled-content style=\"fixed-case\">ranking<\/jats:styled-content> curve (<jats:styled-content style=\"fixed-case\">SUCRA<\/jats:styled-content>) metric; league tables were produced to depict agents' pairwise relative effects. Our secondary outcome was discontinuation due to any adverse event (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>) at 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No significant differences are observed among <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content> inhibitors; however, upadacitinib, cyclosporine, ritlecitinib, and dexamethasone are significantly more effective than minocycline. Psoralen (oral)\u2009+\u2009ultraviolet A (<jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>) and narrow band ultraviolet B (<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) regimens show similar efficacy for repigmentation. Ruxolitinib 1.5% cream (once or twice daily), ruxolitinib 0.5% cream once daily, and ruxolitinib 0.15% cream once daily for 6\u2009months do not differ significantly in efficacy. Mometasone furoate and tacrolimus 0.1% ointment are more effective than tacrolimus 0.03%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70078","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:50:50Z","timestamp":1741733450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relative Impact of Monotherapies for Vitiligo: A Network Meta\u2010Analysis Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc.  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