{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:00:38Z","timestamp":1785549638687,"version":"3.56.0"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris affects up to 80% of individuals aged 11 to 30\u2009years and is one of the most common diseases in the world. Acne and its sequelae, such as redness, hyperpigmentation, irritation, and scarring, can have a deleterious effect on quality of life. Topical therapies are the standard of care, and compliance is central to success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of the study was to evaluate the efficacy of a novel topical formulation (TASG) for the improvement of acne scar appearance and for reducing hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This single\u2010center, open\u2010label clinical trial included healthy subjects (<jats:italic>n<\/jats:italic>\u2009=\u200927, age range 18 to 45\u2009years) presenting with mild to moderate acne scarring and hyperpigmentation. Study duration was 4 visits over a 12\u2010week period. Product was to be applied twice daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant treatment\u2010related adverse events were noted. Data show that 72.5% of subjects had smoother skin and reduced hyperpigmentation (as per observer grading of photographs) and redness at the final week 12 follow\u2010up visit; subjective questionnaire results showed high patient satisfaction, with overall positive impressions of the product itself and its regular use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data show that TASG is a safe and effective therapeutic option for improving the appearance of acne scars and related hyperpigmentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70081","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:18:20Z","timestamp":1741763900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Single\u2010Center, Open Label, Study to Evaluate the Effectiveness of Acne Scar Gel (<scp>ASG<\/scp>) in Improving Acne Scar Appearance and Reducing Hyperpigmentation in Subjects With Mild\u2010To\u2010Moderate Acne Scars"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-6552","authenticated-orcid":false,"given":"Bruce E.","family":"Katz","sequence":"first","affiliation":[{"name":"JUVA Skin &amp; Laser Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithun","family":"Mishu","sequence":"additional","affiliation":[{"name":"JUVA Skin &amp; Laser Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Malayeva","sequence":"additional","affiliation":[{"name":"JUVA Skin &amp; Laser Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113451"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2020.102614"},{"issue":"9","key":"e_1_2_11_5_1","first-page":"12","article-title":"Acne Scarring\u2010Pathogenesis, Evaluation, and Treatment Options","volume":"10","author":"Connolly D.","year":"2017","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00031"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:57:39Z","timestamp":1744225059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jocd.70081"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70081","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70081"}}