{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:28:55Z","timestamp":1783380535728,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Medical literature shows there is no ideal treatment for acne, but topical therapies like benzoyl peroxide, retinoids, and antibiotics have proven to improve mild\u2013moderate cases. Replacing benzoyl peroxide (potentially irritating) with hydrogen peroxide has already been suggested in the medical literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We investigated a medical device, a proprietary combination of hyaluronic acid, hydrogen peroxide, and glycine in mild\u2013moderate acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients of both sexes between \u2265\u200918 and \u2264\u200945\u2009years old, with a Global Acne Grading System score \u2264\u200930, were included. Exclusion criteria were dermal systemic or infectious diseases; allergy to the tested product; pregnant or lactating women; treatment for acne 30\u2009days before baseline; and previous facial aesthetic surgery. Forty patients were treated for 8\u2009weeks several times a day with the tested product and visited at baseline, week 2, week 4, and week 8. Outcomes were decreasing the total number of lesions and the Global Acne Grading System Severity Score, Investigator Global Assessment of Performance with photographs evaluation in blind, Dermatology Life Quality Index, and the Treatment Satisfaction Questionnaire. Adverse events were collected for safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 2\u2010fold decrease in the number of lesions at the final visit (\u221256.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The remaining outcomes evidenced a statistically significant reduction at the final visit. Only 8 adverse events (all mild and related to the tested device) were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results and optimal safety demonstrate that the tested product has a clinical benefit and could be associated with retinoids, as first choice for mild to moderate acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrial.gov\">Clinicaltrial.gov<\/jats:ext-link> as NCT05345093<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70084","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:42:43Z","timestamp":1741758163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Performance and Safety of the Medical Device Ialuxid Gel in the Treatment of Mild\u2013Moderate Acne Vulgaris: An Open\u2010Label, Noncomparative Multicentre Interventional Clinical Trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6581-1338","authenticated-orcid":false,"given":"Meda\u2010Elena","family":"Stefancu","sequence":"first","affiliation":[{"name":"S.C. Salvosan Ciobanca S.R.L.  Zal\u0103u Jud Salaj Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9931-6432","authenticated-orcid":false,"given":"Dionisio Franco","family":"Barattini","sequence":"additional","affiliation":[{"name":"Opera CRO, A TIGERMED Company  Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9687-606X","authenticated-orcid":false,"given":"Ionel","family":"Botnaru","sequence":"additional","affiliation":[{"name":"Darzas Aesthetic  Oradea Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8601-7785","authenticated-orcid":false,"given":"Carmen","family":"Vizman","sequence":"additional","affiliation":[{"name":"Nova\u2010Clin Medical Research Center S.R.L.  Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9725-3518","authenticated-orcid":false,"given":"Luca","family":"Stucchi","sequence":"additional","affiliation":[{"name":"BMG Pharma SpA  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5568-5916","authenticated-orcid":false,"given":"Luca","family":"Barattini","sequence":"additional","affiliation":[{"name":"TIGERMED Italy Srl IT Department  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010018\u201007429\u20103"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26154489"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/497143"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S266320"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)60321\u20108"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12706"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.078"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0160\u20103450(15)31030\u20108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079902125001523"},{"issue":"10","key":"e_1_2_10_12_1","first-page":"50","article-title":"Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide\u2010Based Kit Versus a Benzoyl Peroxide\u2010Based Kit in Mild\u2010To\u2010Moderate Acne","volume":"9","author":"Veraldi S.","year":"2016","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13776"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2004.06067.x"},{"issue":"3","key":"e_1_2_10_15_1","first-page":"287","article-title":"Efficacy and Tolerability of a Topical Gel Containing 3% Hydrogen Peroxide, 1.5% Salicylic Acid and 4% D\u2010Panthenol in the Treatment of Mild\u2010Moderate Acne","volume":"151","author":"Fabbrocini G.","year":"2016","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"issue":"2","key":"e_1_2_10_16_1","first-page":"232","article-title":"Combination Therapy With Hydrogen Peroxide (4%), Salicylic Acid (0.5%) and D\u2010Panthenol (4%): Efficacy and Skyn Tolerability in Common Acne Vulgaris During Sun Exposure Period","volume":"20","author":"Ricci F.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12237"},{"issue":"6","key":"e_1_2_10_18_1","first-page":"441","article-title":"Hyaluronic Acid in Dermatology","volume":"15","author":"Keen M. 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