{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:00:38Z","timestamp":1791820838215,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Forehead contouring can be achieved using injectable fillers. VYC\u201017.5L is a filler containing 17.5\u2009mg\/mL of hyaluronic acid (HA) with lidocaine (3\u2009mg\/mL) for the treatment of skin depressions due to premature aging. Prior studies have demonstrated the safety and efficacy of VYC\u201017.5L in nasolabial folds, lips, and radial cheek lines, but little has been published on the effectiveness of VYC17.5L for forehead contouring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This prospective, open\u2010label, post\u2010marketing study conducted in France evaluated the effectiveness and safety of the HA injectable filler VYC\u201017.5L for use in forehead contouring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults (\u2265\u200918\u2009years) with irregularities of forehead contouring received VYC\u201017.5L in the forehead on Day 1 with an optional touch\u2010up on Day 14. Effectiveness was assessed via investigator\u2010rated Global Aesthetic Improvement Scale (GAIS) of \u201cimproved\u201d or \u201cmuch improved\u201d from baseline at month 1 (M1). Secondary endpoints included participant\u2010rated GAIS and FACE\u2010Q Satisfaction with Facial Appearance. Injection site reactions (ISRs) and adverse device effects (ADEs) were assessed throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty subjects completed the study. The primary endpoint was met: 97.5% of participants showed improvement on the investigator GAIS. Participant GAIS scores were also improved. FACE\u2010Q scores significantly improved from baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and were sustained through month 12. Most ISRs were mild or moderate and resolved in <jats:italic>~<\/jats:italic>1\u2009week. Nine subjects (11%) reported ADEs, with the majority being mild or moderate; the most common ADE was pain, which resolved in &lt;\u200915\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VYC\u201017.5L was well tolerated and effective for improving forehead contouring, as demonstrated by improvements in investigator\u2010 and participant\u2010rated measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70093","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:30:12Z","timestamp":1741771812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Evaluation of <scp>VYC<\/scp>\u201017.<scp>5L<\/scp> for Forehead Contouring: A Prospective, Open\u2010Label, Post\u2010Marketing Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Sofia Ruiz","family":"Del Cueto","sequence":"first","affiliation":[{"name":"Cl\u00ednica Mira and Cueto  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-5278","authenticated-orcid":false,"given":"Fernando Urdiales","family":"Galvez","sequence":"additional","affiliation":[{"name":"Instituto M\u00e9dico Miramar  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gritti","sequence":"additional","affiliation":[{"name":"GRITTI Chirurgia Maxillo Facciale  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Kefalas","sequence":"additional","affiliation":[{"name":"Private Practice  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"de la Guardia","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Kerson","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Marlow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Soft Tissue Augmentation E\u2010Book: Procedures in Cosmetic Dermatology Series","author":"Carruthers A.","year":"2012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/gox.0000000000001858"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010010\u20109606\u20107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2023.03.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0000000000006122"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2022.03.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0000000000003544"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12792"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101741560"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16375"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000002057"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000000939"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.S40581"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000000913"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:57:21Z","timestamp":1744225041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jocd.70093"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70093","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70093"}}