{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:40:00Z","timestamp":1774878000312,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenic alopecia (AGA) is a widespread form of hair loss characterized by the gradual reduction in follicular size and reduced hair density, with unsatisfactory treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study explores the therapeutic potential of a novel fermented extract, <jats:styled-content style=\"fixed-case\"><jats:italic>Thermus thermophilus<\/jats:italic><\/jats:styled-content> fermentation extract (TTFE), in mitigating the effects of AGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The research integrates in\u00a0vitro assays utilizing various hair\u2010growth\u2010related cells with a 12\u2010week clinical trial involving 32 male subjects diagnosed with AGA. A 12\u2010week clinical trial involving 32 male subjects diagnosed with AGA evaluated the effects of topical TTFE application on scalp hydration, transepidermal water loss (TEWL), sebum levels, and hair density using a hydration pin probe, tewameter, and sebumeter and a dermoscope respectively. Moreover, in\u00a0vitro studies analyzed TTFE's effects on cell proliferation, ATP production, inflammation, key signaling pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study revealed that the topical administration of TTFE increased hair density (96.88%), follicular diameter (15%), and scalp hydration while reducing TEWL (47.43%) and sebum production (20%). The in\u00a0vitro results corroborated these findings, showing that TTFE significantly enhanced hDPCs proliferation by increased ATP production and Ki67 expression, and upregulated \u03b2\u2010catenin and downregulated TGF\u2010\u03b22. Additionally, TTFE demonstrated strong anti\u2010inflammation by suppressing the proinflammatory cytokines IL\u20101\u03b2 and IL\u20106 with decreased ROS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TTFE promotes hair growth and scalp health by improving follicles, modulating Wnt\/\u03b2\u2010catenin and TGF\u2010\u03b2 signaling, and reducing inflammation. These findings suggest TTFE holds promise as a potential treatment for AGA, offering a multifaceted approach to restoring hair growth and scalp health by targeting both follicular biology and inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70095","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:05:38Z","timestamp":1741712738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of <scp><i>Thermus thermophilus<\/i><\/scp> Fermentation Extract in Promoting Hair Growth and Improving Scalp Health in Androgenic Alopecia: A Clinical and In\u00a0Vitro Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Yudong","family":"Hu","sequence":"first","affiliation":[{"name":"Yatsen Global Innovation R&amp;D Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Institute of Dermatology Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xusheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangzhou Yatsen Global Co. Ltd  Guangzhou China"},{"name":"School of Life Sciences Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaojuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Yatsen Global Innovation R&amp;D Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangzhou Yatsen Global Co. Ltd  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Institute of Dermatology Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou Yatsen Global Co. Ltd  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1988-518X","authenticated-orcid":false,"given":"Sophia Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yatsen Global Innovation R&amp;D Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410706"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18356"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2003.12.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.490"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(02)00093-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00229.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05785.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1959506"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m07887"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/0953-8984\/22\/32\/323101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16531"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12153"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.082446"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.11.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0765-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13814"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5149"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1099.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01670.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00666.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.5.752"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215549804600310"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00121.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:57:22Z","timestamp":1744225042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jocd.70095"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70095","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70095"}}