{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:27Z","timestamp":1787015547782,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018547","name":"Amorepacific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Wound healing is essential for restoring skin integrity following damage. The skin barrier plays a critical role in protecting against infection, preventing moisture loss, and supporting regeneration. Ceramides, integral components of the lipid matrix, are known to improve skin hydration, reduce inflammation, and accelerate wound healing. However, research on ceramide\u2010based formulations in post\u2010procedural settings remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to evaluate the efficacy of Aestura ATOBARRIER 365 Cream, containing a Lipid Complex with ceramides, cholesterol, and fatty acids, in promoting skin barrier recovery and improving outcomes after barrier disruption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, double\u2010blind, split\u2010face trial was conducted with 30 participants aged 22\u201360\u2009years. Following microneedling, the active formulation was applied to one side of the face and the vehicle formulation to the other, twice daily for 4\u2009weeks. Transepidermal Water Loss (TEWL), erythema, and roughness were measured at baseline, post\u2010application, and at weeks 2 and 4. Participant surveys assessed moisturization, erythema, and overall skin improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both formulations demonstrated significant reductions in TEWL (14%\u201316%) and erythema (~1.7%) by week 4 compared to post\u2010microneedling. High participant satisfaction was also observed, with 93% reporting improved adequate skin hydration and 90% reporting reduced erythema with the active formulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aestura ATOBARRIER 365 Cream with ceramides demonstrated efficacy in improving skin barrier recovery, reducing TEWL, and enhancing skin texture following microneedling. The significant reductions in TEWL, erythema, and roughness highlight its ability to restore the skin's barrier, calm irritation, and refine texture. These findings confirm its role in supporting skin recovery and resilience after dermatological treatments, making it a valuable addition to post\u2010procedure care. While these results support its effectiveness in post\u2010procedural recovery, further research is needed to determine its applicability for other conditions involving compromised skin barriers, such as eczema or rosacea. Additional studies are also warranted to assess long\u2010term efficacy and its potential role in optimizing skin barrier restoration across diverse patient populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70109","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T05:09:00Z","timestamp":1742274540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Split\u2010Face Micro\u2010Needling Study to Evaluate the Efficacy and Consumer Perception of a Novel Moisturization Agent"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9786-4317","authenticated-orcid":false,"given":"Tahreem","family":"Nawaz","sequence":"first","affiliation":[{"name":"Clinical Research Center of New York  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinseob","family":"Shin","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC US, Inc.  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Shieh","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC US, Inc.  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7112-8963","authenticated-orcid":false,"given":"Jane Y.","family":"Yoo","sequence":"additional","affiliation":[{"name":"Clinical Research Center of New York  New York New York USA"},{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534136"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2008.00786.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010021\u201000619\u20102"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2018.09.017"},{"key":"e_1_2_11_6_1","first-page":"169","volume-title":"Advances in Experimental Medicine and Biology","author":"Albeituni S.","year":"2019"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.16175"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12491"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.2020.4796"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14970"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"207","article-title":"A Cohort Study on a Ceramide\u2010Containing Cleanser and Moisturizer Used for Atopic Dermatitis","volume":"93","author":"Lynde C. W.","year":"2014","journal-title":"Cutis"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.s177697"},{"key":"e_1_2_11_13_1","unstructured":"AMOREPACIFIC Research and Innovation Center \u201cThe Skin Penetration and Retention Efficacy of UHD DermaON (Ex\u2010Vivo Skin Explant). Study Code: NCS\u2010SD\u201023\u2010DGO\u20100039\u2010E04 \u201d2024Confidential Report."},{"key":"e_1_2_11_14_1","unstructured":"AMOREPACIFIC Research and Innovation Center \u201cThe Skin Barrier Efficacy of UHD DermaON (Cell). Study Code: NCS\u2010SD\u201023\u2010DGO\u20100039\u2010E01 \u201d2023Confidential Report."},{"key":"e_1_2_11_15_1","unstructured":"AMOREPACIDIC Research and Innovation Center \u201cStructural Analysis of UHD DermaON Lipid Layers Using X\u2010Ray Scattering and Diffraction Methods. Study No.: Material Science\u2010XSD\u2010202308\u2010DermaonUHD \u201d2024Confidential Report."},{"key":"e_1_2_11_16_1","unstructured":"Newtone Technologies \u201cFace Image Analysis for the Evaluation and Comparison of 2 Products Performance on Skin Colour and Homogeneity Over Time. Study No.: COSM\u201004618 \u201d2024Confidential Report."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.68821"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_991_22"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16513"},{"issue":"5","key":"e_1_2_11_20_1","first-page":"30","article-title":"The Efficacy of a Ceramide\u2010Based Cream in Mild\u2010To\u2010Moderate Atopic Dermatitis","volume":"11","author":"Draelos Z. D.","year":"2018","journal-title":"Journal of Clinical and Aesthetic Dermatology"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T14:58:13Z","timestamp":1744210693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jocd.70109"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70109","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2025-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70109"}}