{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:36:16Z","timestamp":1791221776475,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertrophic scars and keloids are human cutaneous fibroproliferative conditions that develop after burns, trauma, surgery, and inflammation. Vitamin D inhibits keloid fibroblast proliferation by reducing TGF\u2010\u03b2\u2010induced extracellular matrix formation, boosting matrix metalloproteinase activity, and reducing inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the effect of intralesional and systemic Vitamin D3 injection on hypertrophic scars and keloids and whether vitamin D3 deficiency increases scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This study included 30 hypertrophic scars and keloid patients divided into groups depending on serum vitamin D levels. Every patient was tested for vitamin D using ELISA. Group I: patients with vitamin D deficiency or insufficiency received a systemic injection of vitamin D (cholecalciferol 200\u2009000 I.U.) once monthly for 3\u2009months with a calcium oral supplement and intralesional vitamin D injections on hypertrophic scars and keloids. Group II: patients with sufficient vitamin D received only intralesional vitamin D injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitamin D deficiency did not affect scar formation or severity (total Vancouver scar scale before assessment) with a <jats:italic>p<\/jats:italic> value &gt;\u20090.05. All instances showed a substantial drop in vascularity, pliability, and total Vancouver scale score (<jats:italic>p<\/jats:italic> value &lt;\u20090.05) following intervention, but no change in scar pigmentation or height. Scar assessment following intervention did not significantly differ between research groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Injection of vitamin on hypertrophic scars and keloids enhances vascularity and pliability in patients with sufficient serum vitamin D levels and those with deficient or insufficient serum vitamin D levels after improving them by systemic injection of vitamin D without any effect on height and pigmentation of scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>NCT06301178<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70118","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T03:05:26Z","timestamp":1743217526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Vitamin D Injection on Keloids and Hypertrophic Scars"],"prefix":"10.1111","volume":"24","author":[{"given":"Amel R.","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammena Y.","family":"Binsaleh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Princess Nourah bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar M.","family":"El\u2010Tahlawi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza M.","family":"El\u2010Amir","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Ishak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Alsubaie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Princess Nourah bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanaa A.","family":"El\u2010Masry","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Tanta University  Tanta Egypt"},{"name":"Pharmacology and Toxicology Department Faculty of Pharmacy, Sinai University, Arish campus  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa M.","family":"Bahaa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Faculty of Pharmacy, Horus University  New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh","family":"Eldesoqui","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences College of Medicine, AlMaarefa University  Riyadh Saudi\u00a0Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Fayoum University  Fayoum 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