{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:20:01Z","timestamp":1790706001636,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Traditional Chinese medicine (TCM) treats skin conditions and delays aging using specific formulas. TCM links skin health to internal organ functions: kidney qi deficiency accelerates aging, whereas spleen deficiency leads to dry, loose skin from insufficient qi and blood. The renowned spleen\u2010tonifying and kidney\u2010nourishing formula \u201cWan An Wan\u201d moisturizes the skin, but its antiageing mechanism remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the development strategy and comprehensive methodological framework for incorporating TCM into cosmetics and to assess the mechanism of action and application potential of the WAW formula in mitigating skin aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In vitro experiments revealed that after optimizing the extraction of the active ingredients of the tailored WAW formula, it effectively inhibited NO production and tyrosinase activity and increased filaggrin, AQP, and HAS2 mRNA expression. Moreover, the active ingredients, including morroniside, were also analyzed separately. Mechanistic studies revealed that the tailored WAW formula upregulated the expression of the TGF\u2010\u03b21 gene associated with ECM production and downregulated the expression of the MMP\u20102\/MMP\u20109 genes associated with ECM degradation, regulating cell behaviors such as migration, adhesion, and proliferation and thereby maintaining the healthy state of the skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, an overall strategy for applying TCM for the development of skin care solutions was established, the potential value of WAW in modern dermatologic applications was revealed, innovative raw materials with comprehensive effects were developed, and new ideas for the fields of cosmetics and dermatology were provided.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70124","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:56:07Z","timestamp":1743483367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Determination via an Integration Strategy of the Potential Dermal\n                    <scp>ECM<\/scp>\n                    Reconstruction Mechanism by Which the\n                    <scp>WAW<\/scp>\n                    Formula Alleviates Skin Aging"],"prefix":"10.1111","volume":"24","author":[{"given":"Yingying","family":"Lin","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Plant Resources Research and Development Beijing Technology and Business University  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhee","family":"Chang","sequence":"additional","affiliation":[{"name":"LG H&amp;H Co., Ltd. LG Science Park R&amp;D Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoojae","family":"Maeng","sequence":"additional","affiliation":[{"name":"LG H&amp;H Co., Ltd. China R&amp;D Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Plant Resources Research and Development Beijing Technology and Business University  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-5223","authenticated-orcid":false,"given":"Xinke","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Plant Resources Research and Development Beijing Technology and Business University  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Meng","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Plant Resources Research and Development Beijing Technology and Business University  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7476-616X","authenticated-orcid":false,"given":"Fan","family":"Yi","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Plant Resources Research and Development Beijing Technology and Business University  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13112130"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010016\u20109470\u20104"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2015.150"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.19319\/j.cnki.issn.1008\u2010021x.2015.21.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010023\u201000818\u20105"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117699"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758\u20102946\u20106\u201013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051407"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945\u2010053X(98)00004\u20103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2008.11.016"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2015.1008332"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.06.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021684"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228693"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.1121"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2009.09.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312641"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2022.1116"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060128"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1565885"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12673"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114735"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.990040"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.16438\/j.0513\u20104870.2022\u20100881"},{"issue":"6","key":"e_1_2_11_26_1","first-page":"1074","article-title":"Saikokeishito Protecting HumanDermal Fibroblast Cell From Oxidative Damage Induced by H2O2","volume":"22","author":"Wang c.","year":"2018","journal-title":"Chinese Journal of Laboratory Diagnosis"},{"issue":"1","key":"e_1_2_11_27_1","first-page":"11","article-title":"Protective Effect of Yupingfeng Powder on Photoaging of Human Skin Fibroblasts Induced by Ultraviolet Radiation","volume":"41","author":"Ma z.","year":"2019","journal-title":"Journal of Youjiang Medical University for Nationalities"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T06:37:55Z","timestamp":1758782275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jocd.70124"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70124","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]},"assertion":[{"value":"2024-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70124"}}