{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:48:06Z","timestamp":1791895686344,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073435"],"award-info":[{"award-number":["82073435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adipose extracellular matrix\/stromal vascular fraction gel (ECM\/SVF\u2010gel) contains adipose\u2010derived stem cells, extracellular matrix, and other cell components, and possesses the ability to promote collagen production and serve as a filling agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the efficacy and safety of ECM\/SVF\u2010gel injection for the treatment of acne scars, compared to CO<jats:sub>2<\/jats:sub> fractional laser (CO<jats:sub>2<\/jats:sub>FL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an open\u2010label, investigator\u2010initiated, assessor\u2010blinded, split\u2010face trial in Xijing Hospital, China, between July 11, 2020, and December 30, 2022. Patients exhibiting moderate to severe acne scars were randomly assigned to a single ECM\/SVF\u2010gel injection on one half of the face or two sessions of CO<jats:sub>2<\/jats:sub>FL treatments on the other half. The primary outcome was the change in total Echelle d'Evaluation Clinique des Cicatrices d'acne (ECCA) score from baseline to 24\u2010week follow\u2010up. Secondary outcomes included the changes in the volume of scars assessed by the Antera 3D software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11 participants were enrolled, and 10 completed the follow\u2010up. The mean age of patients was 27.5\u2009\u00b1\u20094.2, 7 female and four male, seven with Fitzpatrick skin Type III and four with Type IV. At 24weeks, the mean change in ECCA score was \u221260.25 on the side of ECM\/SVF\u2010gel injection and\u2009\u2212\u200943.25 on the side of CO<jats:sub>2<\/jats:sub>FL treatment (difference:\u221217.00 [95% CI: \u221224.56 to \u22129.44], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Antera 3D photography analysis showed that the mean change in scar volume was \u221233.17% on ECM\/SVF\u2010gel injection and \u221219.69% on CO<jats:sub>2<\/jats:sub>FL (difference: \u221213.48% [95% CI:\u221222.16% to \u22124.79%], <jats:italic>p<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ECM\/SVF\u2010gel injection is an effective and safe approach in the treatment of acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> number: NCT06116162<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70131","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T05:57:37Z","timestamp":1742709457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of the Effects of Adipose Extracellular Matrix\/Stromal Vascular Fraction Gel Injection and <scp>CO<sub>2<\/sub><\/scp> Fractional Laser on Atrophic Acne Scar in Asians Through a 24\u2010Week Prospective, Randomized, Split\u2010Face Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Tao","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Air Force Medical University  Xi'an China"},{"name":"Xi'an Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital, Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8080-9883","authenticated-orcid":false,"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Air Force Medical University  Xi'an 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